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A Review on the Association between Glucagon-Like Peptide-1 Receptor Agonists and Thyroid Cancer
المؤلفون المشاركون
Shih, Shyang-Rong
Tseng, Chin-Hsiao
Chiu, Wei-Yih
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
There is a concern on the risk of thyroid cancer associated with glucagon-like peptide-1 (GLP-1) analogs including liraglutide and exenatide.
In this article, we review related experimental studies, clinical trials and observational human studies currently available.
In rodents, liraglutide activated the GLP-1 receptors on C-cells, causing an increased incidence of C-cell neoplasia.
Animal experiments with monkeys demonstrated no increase in calcitonin release and no C-cell proliferation after long-term liraglutide administration.
Longitudinal 2-year data from clinical trials do not support any significant risk for the activation or growth of C-cell cancer in humans in response to liraglutide.
However, an analysis of the FDA adverse event reporting system database suggested an increased risk for thyroid cancer associated with exenatide after its marketing.
Noticeably, a recent study discovered that GLP-1 receptor could also be expressed in human papillary thyroid carcinomas (PTC), but the impact of GLP-1 analogs on PTC is not known.
Therefore, GLP-1 analogs might increase the risk of thyroid C-cell pathology in rodents, but its risk in humans awaits confirmation.
Since GLP-1 receptor is also expressed in PTC besides C-cells, it is important to investigate the actions of GLP-1 on different subtypes of thyroid cancer in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chiu, Wei-Yih& Shih, Shyang-Rong& Tseng, Chin-Hsiao. 2012. A Review on the Association between Glucagon-Like Peptide-1 Receptor Agonists and Thyroid Cancer. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-508475
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chiu, Wei-Yih…[et al.]. A Review on the Association between Glucagon-Like Peptide-1 Receptor Agonists and Thyroid Cancer. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-508475
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chiu, Wei-Yih& Shih, Shyang-Rong& Tseng, Chin-Hsiao. A Review on the Association between Glucagon-Like Peptide-1 Receptor Agonists and Thyroid Cancer. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-508475
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508475
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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