A Review on the Association between Glucagon-Like Peptide-1 Receptor Agonists and Thyroid Cancer
Joint Authors
Shih, Shyang-Rong
Tseng, Chin-Hsiao
Chiu, Wei-Yih
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
There is a concern on the risk of thyroid cancer associated with glucagon-like peptide-1 (GLP-1) analogs including liraglutide and exenatide.
In this article, we review related experimental studies, clinical trials and observational human studies currently available.
In rodents, liraglutide activated the GLP-1 receptors on C-cells, causing an increased incidence of C-cell neoplasia.
Animal experiments with monkeys demonstrated no increase in calcitonin release and no C-cell proliferation after long-term liraglutide administration.
Longitudinal 2-year data from clinical trials do not support any significant risk for the activation or growth of C-cell cancer in humans in response to liraglutide.
However, an analysis of the FDA adverse event reporting system database suggested an increased risk for thyroid cancer associated with exenatide after its marketing.
Noticeably, a recent study discovered that GLP-1 receptor could also be expressed in human papillary thyroid carcinomas (PTC), but the impact of GLP-1 analogs on PTC is not known.
Therefore, GLP-1 analogs might increase the risk of thyroid C-cell pathology in rodents, but its risk in humans awaits confirmation.
Since GLP-1 receptor is also expressed in PTC besides C-cells, it is important to investigate the actions of GLP-1 on different subtypes of thyroid cancer in the future.
American Psychological Association (APA)
Chiu, Wei-Yih& Shih, Shyang-Rong& Tseng, Chin-Hsiao. 2012. A Review on the Association between Glucagon-Like Peptide-1 Receptor Agonists and Thyroid Cancer. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-508475
Modern Language Association (MLA)
Chiu, Wei-Yih…[et al.]. A Review on the Association between Glucagon-Like Peptide-1 Receptor Agonists and Thyroid Cancer. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-508475
American Medical Association (AMA)
Chiu, Wei-Yih& Shih, Shyang-Rong& Tseng, Chin-Hsiao. A Review on the Association between Glucagon-Like Peptide-1 Receptor Agonists and Thyroid Cancer. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-508475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508475