Optimisation and In Vivo Evaluation of Pectin Based Drug Delivery System Containing Curcumin for Colon
المؤلفون المشاركون
Deshmukh, Hemant
Momin, Munira
Butte, Kishor
المصدر
International Journal of Biomaterials
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The higher incidences of side effects of existing drugs have shifted researchers and clinicians to explore the dietary phytoconstituents for its therapeutic potentials.
The present study is based on compression coated curcumin tablet for the colon.
Curcumin has anti-inflammatory and antioxidant properties.
Curcumin presents a bioavailability problem due to poor solubility.
An inclusion complex was formed with hydroxypropyl-β-cyclodextrin to enhance the solubility.
In this study, the core tablet of curcumin inclusion complex was compressed between the layers of polymer blend of pectin and Eudragit S100.
The 32 full factorial design was utilised for optimization of the formulation.
The polymer ratio (X1) and coat thickness (X2) presented significant effects on the selected responses, i.e., percent drug release after 4 hours (Y240) and difference in percent drug release between 4th and 6th hour (Ydiff) in presence of pectinase enzyme.
The results revealed that higher coat weight (600 mg) and higher level of pectin ratio (70% w/w) protected the curcumin tablet till ascending colon.
The in vivo studies by roentgenography method using human volunteers supported these observations.
Hence, it can be concluded that the combination of pectin and Eudrgit S100 makes the system biodegradable and pH dependent for targeting the drug to the colon.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Butte, Kishor& Momin, Munira& Deshmukh, Hemant. 2014. Optimisation and In Vivo Evaluation of Pectin Based Drug Delivery System Containing Curcumin for Colon. International Journal of Biomaterials،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-508486
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Butte, Kishor…[et al.]. Optimisation and In Vivo Evaluation of Pectin Based Drug Delivery System Containing Curcumin for Colon. International Journal of Biomaterials No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-508486
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Butte, Kishor& Momin, Munira& Deshmukh, Hemant. Optimisation and In Vivo Evaluation of Pectin Based Drug Delivery System Containing Curcumin for Colon. International Journal of Biomaterials. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-508486
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508486
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر