![](/images/graphics-bg.png)
Optimisation and In Vivo Evaluation of Pectin Based Drug Delivery System Containing Curcumin for Colon
Joint Authors
Deshmukh, Hemant
Momin, Munira
Butte, Kishor
Source
International Journal of Biomaterials
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The higher incidences of side effects of existing drugs have shifted researchers and clinicians to explore the dietary phytoconstituents for its therapeutic potentials.
The present study is based on compression coated curcumin tablet for the colon.
Curcumin has anti-inflammatory and antioxidant properties.
Curcumin presents a bioavailability problem due to poor solubility.
An inclusion complex was formed with hydroxypropyl-β-cyclodextrin to enhance the solubility.
In this study, the core tablet of curcumin inclusion complex was compressed between the layers of polymer blend of pectin and Eudragit S100.
The 32 full factorial design was utilised for optimization of the formulation.
The polymer ratio (X1) and coat thickness (X2) presented significant effects on the selected responses, i.e., percent drug release after 4 hours (Y240) and difference in percent drug release between 4th and 6th hour (Ydiff) in presence of pectinase enzyme.
The results revealed that higher coat weight (600 mg) and higher level of pectin ratio (70% w/w) protected the curcumin tablet till ascending colon.
The in vivo studies by roentgenography method using human volunteers supported these observations.
Hence, it can be concluded that the combination of pectin and Eudrgit S100 makes the system biodegradable and pH dependent for targeting the drug to the colon.
American Psychological Association (APA)
Butte, Kishor& Momin, Munira& Deshmukh, Hemant. 2014. Optimisation and In Vivo Evaluation of Pectin Based Drug Delivery System Containing Curcumin for Colon. International Journal of Biomaterials،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-508486
Modern Language Association (MLA)
Butte, Kishor…[et al.]. Optimisation and In Vivo Evaluation of Pectin Based Drug Delivery System Containing Curcumin for Colon. International Journal of Biomaterials No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-508486
American Medical Association (AMA)
Butte, Kishor& Momin, Munira& Deshmukh, Hemant. Optimisation and In Vivo Evaluation of Pectin Based Drug Delivery System Containing Curcumin for Colon. International Journal of Biomaterials. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-508486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508486