Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism
المؤلفون المشاركون
Feng, Kai
Zhang, Qian
Li, Wenhui
Wang, Heng
Xiang, Hongding
Sun, Xiaofang
Yuan, Tao
Wang, Tong
Sun, Qi
Xiao, Xin-Hua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-09-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Berberine is known to improve glucose and lipid metabolism disorders, but the mechanism is still under investigation.
In this paper, we explored the effects of berberine on the weight, glucose levels, lipid metabolism, and serum insulin of KKAy mice and investigated its possible glucose and lipid-regulating mechanism.
We randomly divided KKAy mice into two groups: berberine group (treated with 250 mg/kg/d berberine) and control group.
Fasting blood glucose (FBG), weight, total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c), and fasting serum insulin were measured in both groups.
The oral glucose tolerance test (OGTT) was performed.
RT2 PCR array gene expression analysis was performed using skeletal muscle of KKAy mice.
Our data demonstrated that berberine significantly decreased FBG, area under the curve (AUC), fasting serum insulin (FINS), homeostasis model assessment insulin resistance (HOMA-IR) index, TC, and TG, compared with those of control group.
RT2 profiler PCR array analysis showed that berberine upregulated the expression of glucose transporter 4 (GLUT4), mitogen-activated protein kinase 14 (MAPK14), MAPK8(c-jun N-terminal kinase, JNK), peroxisome proliferator-activated receptor α (PPARα), uncoupling protein 2 (UCP2), and hepatic nuclear factor 4α(HNF4α), whereas it downregulated the expression of PPARγ, CCAAT/enhancer-binding protein (CEBP), PPARγ coactivator 1α(PGC 1α), and resistin.
These results suggest that berberine moderates glucose and lipid metabolism through a multipathway mechanism that includes AMP-activated protein kinase-(AMPK-) p38 MAPK-GLUT4, JNK pathway, and PPARα pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Qian& Xiao, Xin-Hua& Feng, Kai& Wang, Tong& Li, Wenhui& Yuan, Tao…[et al.]. 2010. Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-508529
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Qian…[et al.]. Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-508529
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Qian& Xiao, Xin-Hua& Feng, Kai& Wang, Tong& Li, Wenhui& Yuan, Tao…[et al.]. Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-508529
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508529
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر