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Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism
Joint Authors
Feng, Kai
Zhang, Qian
Li, Wenhui
Wang, Heng
Xiang, Hongding
Sun, Xiaofang
Yuan, Tao
Wang, Tong
Sun, Qi
Xiao, Xin-Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Berberine is known to improve glucose and lipid metabolism disorders, but the mechanism is still under investigation.
In this paper, we explored the effects of berberine on the weight, glucose levels, lipid metabolism, and serum insulin of KKAy mice and investigated its possible glucose and lipid-regulating mechanism.
We randomly divided KKAy mice into two groups: berberine group (treated with 250 mg/kg/d berberine) and control group.
Fasting blood glucose (FBG), weight, total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c), and fasting serum insulin were measured in both groups.
The oral glucose tolerance test (OGTT) was performed.
RT2 PCR array gene expression analysis was performed using skeletal muscle of KKAy mice.
Our data demonstrated that berberine significantly decreased FBG, area under the curve (AUC), fasting serum insulin (FINS), homeostasis model assessment insulin resistance (HOMA-IR) index, TC, and TG, compared with those of control group.
RT2 profiler PCR array analysis showed that berberine upregulated the expression of glucose transporter 4 (GLUT4), mitogen-activated protein kinase 14 (MAPK14), MAPK8(c-jun N-terminal kinase, JNK), peroxisome proliferator-activated receptor α (PPARα), uncoupling protein 2 (UCP2), and hepatic nuclear factor 4α(HNF4α), whereas it downregulated the expression of PPARγ, CCAAT/enhancer-binding protein (CEBP), PPARγ coactivator 1α(PGC 1α), and resistin.
These results suggest that berberine moderates glucose and lipid metabolism through a multipathway mechanism that includes AMP-activated protein kinase-(AMPK-) p38 MAPK-GLUT4, JNK pathway, and PPARα pathway.
American Psychological Association (APA)
Zhang, Qian& Xiao, Xin-Hua& Feng, Kai& Wang, Tong& Li, Wenhui& Yuan, Tao…[et al.]. 2010. Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-508529
Modern Language Association (MLA)
Zhang, Qian…[et al.]. Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-508529
American Medical Association (AMA)
Zhang, Qian& Xiao, Xin-Hua& Feng, Kai& Wang, Tong& Li, Wenhui& Yuan, Tao…[et al.]. Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-508529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508529