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Peptide Receptor Targeting in Cancer : The Somatostatin Paradigm
المؤلفون المشاركون
Thellung, Stefano
Gatti, Monica
Würth, Roberto
Barbieri, Federica
Villa, Valentina
Nizzari, Mario
Florio, Tullio
Bajetto, Adriana
Corsaro, Alessandro
Pattarozzi, Alessandra
المصدر
International Journal of Peptides
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-07
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Peptide receptors involved in pathophysiological processes represent promising therapeutic targets.
Neuropeptide somatostatin (SST) is produced by specialized cells in a large number of human organs and tissues.
SST primarily acts as inhibitor of endocrine and exocrine secretion via the activation of five G-protein-coupled receptors, named sst1–5, while in central nervous system, SST acts as a neurotransmitter/neuromodulator, regulating locomotory and cognitive functions.
Critical points of SST/SST receptor biology, such as signaling pathways of individual receptor subtypes, homo- and heterodimerization, trafficking, and cross-talk with growth factor receptors, have been extensively studied, although functions associated with several pathological conditions, including cancer, are still not completely unraveled.
Importantly, SST exerts antiproliferative and antiangiogenic effects on cancer cells in vitro, and on experimental tumors in vivo.
Moreover, SST agonists are clinically effective as antitumor agents for pituitary adenomas and gastro-pancreatic neuroendocrine tumors.
However, SST receptors being expressed by tumor cells of various tumor histotypes, their pharmacological use is potentially extendible to other cancer types, although to date no significant results have been obtained.
In this paper the most recent findings on the expression and functional roles of SST and SST receptors in tumor cells are discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barbieri, Federica& Bajetto, Adriana& Pattarozzi, Alessandra& Gatti, Monica& Würth, Roberto& Thellung, Stefano…[et al.]. 2013. Peptide Receptor Targeting in Cancer : The Somatostatin Paradigm. International Journal of Peptides،Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-508668
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barbieri, Federica…[et al.]. Peptide Receptor Targeting in Cancer : The Somatostatin Paradigm. International Journal of Peptides No. 2013 (2013), pp.1-20.
https://search.emarefa.net/detail/BIM-508668
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barbieri, Federica& Bajetto, Adriana& Pattarozzi, Alessandra& Gatti, Monica& Würth, Roberto& Thellung, Stefano…[et al.]. Peptide Receptor Targeting in Cancer : The Somatostatin Paradigm. International Journal of Peptides. 2013. Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-508668
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508668
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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