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Peptide Receptor Targeting in Cancer : The Somatostatin Paradigm
Joint Authors
Thellung, Stefano
Gatti, Monica
Würth, Roberto
Barbieri, Federica
Villa, Valentina
Nizzari, Mario
Florio, Tullio
Bajetto, Adriana
Corsaro, Alessandro
Pattarozzi, Alessandra
Source
International Journal of Peptides
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-07
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Peptide receptors involved in pathophysiological processes represent promising therapeutic targets.
Neuropeptide somatostatin (SST) is produced by specialized cells in a large number of human organs and tissues.
SST primarily acts as inhibitor of endocrine and exocrine secretion via the activation of five G-protein-coupled receptors, named sst1–5, while in central nervous system, SST acts as a neurotransmitter/neuromodulator, regulating locomotory and cognitive functions.
Critical points of SST/SST receptor biology, such as signaling pathways of individual receptor subtypes, homo- and heterodimerization, trafficking, and cross-talk with growth factor receptors, have been extensively studied, although functions associated with several pathological conditions, including cancer, are still not completely unraveled.
Importantly, SST exerts antiproliferative and antiangiogenic effects on cancer cells in vitro, and on experimental tumors in vivo.
Moreover, SST agonists are clinically effective as antitumor agents for pituitary adenomas and gastro-pancreatic neuroendocrine tumors.
However, SST receptors being expressed by tumor cells of various tumor histotypes, their pharmacological use is potentially extendible to other cancer types, although to date no significant results have been obtained.
In this paper the most recent findings on the expression and functional roles of SST and SST receptors in tumor cells are discussed.
American Psychological Association (APA)
Barbieri, Federica& Bajetto, Adriana& Pattarozzi, Alessandra& Gatti, Monica& Würth, Roberto& Thellung, Stefano…[et al.]. 2013. Peptide Receptor Targeting in Cancer : The Somatostatin Paradigm. International Journal of Peptides،Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-508668
Modern Language Association (MLA)
Barbieri, Federica…[et al.]. Peptide Receptor Targeting in Cancer : The Somatostatin Paradigm. International Journal of Peptides No. 2013 (2013), pp.1-20.
https://search.emarefa.net/detail/BIM-508668
American Medical Association (AMA)
Barbieri, Federica& Bajetto, Adriana& Pattarozzi, Alessandra& Gatti, Monica& Würth, Roberto& Thellung, Stefano…[et al.]. Peptide Receptor Targeting in Cancer : The Somatostatin Paradigm. International Journal of Peptides. 2013. Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-508668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508668