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Rapidly In Situ Forming Platelet-Rich Plasma Gel Enhances Angiogenic Responses and Augments Early Wound Healing after Open Abdomen
المؤلفون المشاركون
Gu, Guosheng
Ren, Jianan
Wu, Yin
Li, Jieshou
Hu, Dong
Ding, Chao
Zhou, Bo
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
The purposes of our present study were to evaluate the potential of platelet-rich plasma gel to enhance granulation tissue formation after open abdomen and to examine whether the effect was attributable to stimulating rapid neovascularization.
Methods.
Twenty-four rats underwent colon ascendens stent peritonitis surgery to induce sepsis, followed by intraperitoneal injection of nitrogen to create intra-abdominal hypertension.
Four hours later, laparotomies were performed.
The rats were randomized into three groups (n=8 for each group): control, platelet-poor plasma (PPP), and platelet-rich plasma (PRP) groups.
One week after the treatment, granulation tissue formation and angiogenesis were evaluated by histological and laser Doppler analysis.
Results.
The resultant platelet count in platelet-rich plasma was higher than that of PPP.
The concentrations of platelet-derived growth factor BB, transforming growth factor β-1, and vascular endothelial growth factor in PRP were significantly higher when compared with that of PPP.
Myofibroblast count, granulation tissue thickness, vessel numbers, and blood perfusion were increased in PRP group, followed by PPP group, with control being the least.
Conclusion.
Rapidly in situ forming platelet-rich plasma gel promoted remarkable neovascularization and early wound healing after open abdomen and may lead to novel and effective treatments for open abdominal wounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Bo& Ren, Jianan& Ding, Chao& Wu, Yin& Hu, Dong& Gu, Guosheng…[et al.]. 2013. Rapidly In Situ Forming Platelet-Rich Plasma Gel Enhances Angiogenic Responses and Augments Early Wound Healing after Open Abdomen. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508722
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Bo…[et al.]. Rapidly In Situ Forming Platelet-Rich Plasma Gel Enhances Angiogenic Responses and Augments Early Wound Healing after Open Abdomen. Gastroenterology Research and Practice No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-508722
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Bo& Ren, Jianan& Ding, Chao& Wu, Yin& Hu, Dong& Gu, Guosheng…[et al.]. Rapidly In Situ Forming Platelet-Rich Plasma Gel Enhances Angiogenic Responses and Augments Early Wound Healing after Open Abdomen. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508722
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508722
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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