Rapidly In Situ Forming Platelet-Rich Plasma Gel Enhances Angiogenic Responses and Augments Early Wound Healing after Open Abdomen
Joint Authors
Gu, Guosheng
Ren, Jianan
Wu, Yin
Li, Jieshou
Hu, Dong
Ding, Chao
Zhou, Bo
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The purposes of our present study were to evaluate the potential of platelet-rich plasma gel to enhance granulation tissue formation after open abdomen and to examine whether the effect was attributable to stimulating rapid neovascularization.
Methods.
Twenty-four rats underwent colon ascendens stent peritonitis surgery to induce sepsis, followed by intraperitoneal injection of nitrogen to create intra-abdominal hypertension.
Four hours later, laparotomies were performed.
The rats were randomized into three groups (n=8 for each group): control, platelet-poor plasma (PPP), and platelet-rich plasma (PRP) groups.
One week after the treatment, granulation tissue formation and angiogenesis were evaluated by histological and laser Doppler analysis.
Results.
The resultant platelet count in platelet-rich plasma was higher than that of PPP.
The concentrations of platelet-derived growth factor BB, transforming growth factor β-1, and vascular endothelial growth factor in PRP were significantly higher when compared with that of PPP.
Myofibroblast count, granulation tissue thickness, vessel numbers, and blood perfusion were increased in PRP group, followed by PPP group, with control being the least.
Conclusion.
Rapidly in situ forming platelet-rich plasma gel promoted remarkable neovascularization and early wound healing after open abdomen and may lead to novel and effective treatments for open abdominal wounds.
American Psychological Association (APA)
Zhou, Bo& Ren, Jianan& Ding, Chao& Wu, Yin& Hu, Dong& Gu, Guosheng…[et al.]. 2013. Rapidly In Situ Forming Platelet-Rich Plasma Gel Enhances Angiogenic Responses and Augments Early Wound Healing after Open Abdomen. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508722
Modern Language Association (MLA)
Zhou, Bo…[et al.]. Rapidly In Situ Forming Platelet-Rich Plasma Gel Enhances Angiogenic Responses and Augments Early Wound Healing after Open Abdomen. Gastroenterology Research and Practice No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-508722
American Medical Association (AMA)
Zhou, Bo& Ren, Jianan& Ding, Chao& Wu, Yin& Hu, Dong& Gu, Guosheng…[et al.]. Rapidly In Situ Forming Platelet-Rich Plasma Gel Enhances Angiogenic Responses and Augments Early Wound Healing after Open Abdomen. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508722