Azithromycin Prevents Pregnancy Loss : Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats
المؤلف
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-24
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss.
Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromycin group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy; lipopolysaccharide group, where LPS was administered intravenously via the tail vein at 160 μg kg−1 on day 10 of pregnancy; and the azithromycin + LPS group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy and LPS was administered intravenously at 160 μg kg−1 on day 10 of pregnancy.
Blood samples were obtained from the tail vein on day 10 of the experiment.
Pregnancy rates were determined.
Tumor necrosis factor-alpha (TNF-α) and interleukin (IL-10) levels were measured by ELISA.
Azithromycin prevented (P<0.05) LPS-induced pregnancy loss.
Higher TNF-α and IL-10 levels were measured (P<0.05) in the LPS and azithromycin + LPS groups, respectively.
In conclusion, azithromycin may be useful in infection- or endotoxemia-dependent pregnancy loss.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Er, Ayse. 2013. Azithromycin Prevents Pregnancy Loss : Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-508859
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Er, Ayse. Azithromycin Prevents Pregnancy Loss : Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats. Mediators of Inflammation No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-508859
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Er, Ayse. Azithromycin Prevents Pregnancy Loss : Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-508859
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508859
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر