Azithromycin Prevents Pregnancy Loss : Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss.
Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromycin group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy; lipopolysaccharide group, where LPS was administered intravenously via the tail vein at 160 μg kg−1 on day 10 of pregnancy; and the azithromycin + LPS group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy and LPS was administered intravenously at 160 μg kg−1 on day 10 of pregnancy.
Blood samples were obtained from the tail vein on day 10 of the experiment.
Pregnancy rates were determined.
Tumor necrosis factor-alpha (TNF-α) and interleukin (IL-10) levels were measured by ELISA.
Azithromycin prevented (P<0.05) LPS-induced pregnancy loss.
Higher TNF-α and IL-10 levels were measured (P<0.05) in the LPS and azithromycin + LPS groups, respectively.
In conclusion, azithromycin may be useful in infection- or endotoxemia-dependent pregnancy loss.
American Psychological Association (APA)
Er, Ayse. 2013. Azithromycin Prevents Pregnancy Loss : Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-508859
Modern Language Association (MLA)
Er, Ayse. Azithromycin Prevents Pregnancy Loss : Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats. Mediators of Inflammation No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-508859
American Medical Association (AMA)
Er, Ayse. Azithromycin Prevents Pregnancy Loss : Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-508859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508859