The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses
المؤلفون المشاركون
Sekine, Shiori
Ichijo, Hidenori
Takeda, Kohsuke
Kanamaru, Yusuke
المصدر
Journal of Signal Transduction
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
To maintain cellular homeostasis, cells are equipped with precise systems that trigger the appropriate stress responses.
Mitochondria not only provide cellular energy but also integrate stress response signaling pathways, including those regulating cell death.
Several lines of evidence suggest that the mitochondrial proteins that function in this process, such as Bcl-2 family proteins in apoptosis and phosphoglycerate mutase family member 5 (PGAM5) in necroptosis, are regulated by several kinases.
It has also been suggested that the phosphorylation-dependent regulation of mitochondrial fission machinery, dynamin-related protein 1 (Drp1), facilitates appropriate cellular stress responses.
However, mitochondria themselves are also damaged by various stresses.
To avoid the deleterious effects exerted by damaged mitochondria, cells remove these mitochondria in a selective autophagic degradation process called mitophagy.
Interestingly, several kinases, such as PTEN-induced putative kinase 1 (PINK1) in mammals and stress-responsive mitogen-activated protein (MAP) kinases in yeast, have recently been shown to be involved in mitophagy.
In this paper, we focus on the phosphorylation-dependent regulation of mitochondrial proteins and discuss the roles of this regulation in the mitochondrial and cellular stress responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kanamaru, Yusuke& Sekine, Shiori& Ichijo, Hidenori& Takeda, Kohsuke. 2012. The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-509137
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kanamaru, Yusuke…[et al.]. The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses. Journal of Signal Transduction No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-509137
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kanamaru, Yusuke& Sekine, Shiori& Ichijo, Hidenori& Takeda, Kohsuke. The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-509137
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-509137
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر