The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses
Joint Authors
Sekine, Shiori
Ichijo, Hidenori
Takeda, Kohsuke
Kanamaru, Yusuke
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
To maintain cellular homeostasis, cells are equipped with precise systems that trigger the appropriate stress responses.
Mitochondria not only provide cellular energy but also integrate stress response signaling pathways, including those regulating cell death.
Several lines of evidence suggest that the mitochondrial proteins that function in this process, such as Bcl-2 family proteins in apoptosis and phosphoglycerate mutase family member 5 (PGAM5) in necroptosis, are regulated by several kinases.
It has also been suggested that the phosphorylation-dependent regulation of mitochondrial fission machinery, dynamin-related protein 1 (Drp1), facilitates appropriate cellular stress responses.
However, mitochondria themselves are also damaged by various stresses.
To avoid the deleterious effects exerted by damaged mitochondria, cells remove these mitochondria in a selective autophagic degradation process called mitophagy.
Interestingly, several kinases, such as PTEN-induced putative kinase 1 (PINK1) in mammals and stress-responsive mitogen-activated protein (MAP) kinases in yeast, have recently been shown to be involved in mitophagy.
In this paper, we focus on the phosphorylation-dependent regulation of mitochondrial proteins and discuss the roles of this regulation in the mitochondrial and cellular stress responses.
American Psychological Association (APA)
Kanamaru, Yusuke& Sekine, Shiori& Ichijo, Hidenori& Takeda, Kohsuke. 2012. The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-509137
Modern Language Association (MLA)
Kanamaru, Yusuke…[et al.]. The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses. Journal of Signal Transduction No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-509137
American Medical Association (AMA)
Kanamaru, Yusuke& Sekine, Shiori& Ichijo, Hidenori& Takeda, Kohsuke. The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-509137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509137