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Development and Characterization of Polyphenon 60 and Caffeine Microemulsion for Enhanced Antibacterial Activity
المؤلفون المشاركون
Dang, Shweta
Bansal, Rakhi
Gupta, Sonal
Ali, Javed
Gabrani, Reema
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Green tea catechins and caffeine have exhibited antibacterial activity; however, their use is limited by lack of stability and effective delivery systems.
Polyphenon 60 (P60) and caffeine were encapsulated in a single microemulsion (ME) formulation with an objective to lower the minimum inhibitory concentrations (MICs) of the individual agents against selected pathogens (S.
epidermidis and E.
coli).
Combination of two natural compounds would advocate two different mechanisms on the bacterial growth thereby providing for better antibacterial activity.
Thermodynamically stable ME was developed and characterized with an average particle size of 17.58 nm, further confirmed by TEM analysis.
Antibacterial studies included chequerboard microdilution assay to determine the MIC and fractional inhibitory concentration (FIC) of both the natural compounds individually and in combination.
MIC and FIC results indicated that the combination of the above two natural compounds was proficient in lowering the MICs of individual agents.
Results of DPPH assay indicated that ME system preserved the long term antioxidative potential of P60 and caffeine.
The cytotoxicity of the optimized formulation on Vero cell line by MTT assay was found to be nontoxic to mammalian cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gupta, Sonal& Bansal, Rakhi& Ali, Javed& Gabrani, Reema& Dang, Shweta. 2014. Development and Characterization of Polyphenon 60 and Caffeine Microemulsion for Enhanced Antibacterial Activity. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-509219
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gupta, Sonal…[et al.]. Development and Characterization of Polyphenon 60 and Caffeine Microemulsion for Enhanced Antibacterial Activity. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-509219
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gupta, Sonal& Bansal, Rakhi& Ali, Javed& Gabrani, Reema& Dang, Shweta. Development and Characterization of Polyphenon 60 and Caffeine Microemulsion for Enhanced Antibacterial Activity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-509219
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-509219
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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