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The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma
المؤلفون المشاركون
Erdemir, Fikret
Uluocak, Nihat
Atılgan, Doğan
Parlaktas, Bekir Suha
Ozyurt, Huseyin
Erkorkmaz, Unal
Kolukcu, Engin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-23
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objectives.
The aim of this study was to investigate the association of RCC and Ala16Val polymorphism in Turkish patients with RCC.
Materials and Methods.
A total of 41 patients with RCC who underwent radical or partial nephrectomy in our clinic and 50 healthy volunteers living in the same geographic area were included in this study.
DNA samples from serum of RCC patients and controls were genotyped for MnSOD polymorphism analysis.
Genotype ratios and allele frequencies were compared between two groups and odd ratios with 95% confidence intervals were calculated statistically.
A P value of <0.05 was considered statistically significant.
Results.
There was a significant difference in the MnSOD genotype distributions between the RCC patients and the controls in terms of Ala/Ala+Ala/Val and Val/Val genotypes (P=0.039).
The Ala/Ala+Ala/Val genotypes were found significantly suspicious for RCC with an OR of 2.64 (95% CI = 1.06–6.69, P= 0.039).
In addition, Ala allele was found significantly suspicious for RCC with an OR of 2.26 (95% CI = 1.24–4.12, P= 0.009).
Conclusion.
Our study indicated that MnSOD Ala16Val polymorphism may be one of the many genetic factors for renal cancer susceptibility in Turkish patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Atılgan, Doğan& Parlaktas, Bekir Suha& Uluocak, Nihat& Kolukcu, Engin& Erdemir, Fikret& Ozyurt, Huseyin…[et al.]. 2014. The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma. Advances in Urology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-509270
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Atılgan, Doğan…[et al.]. The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma. Advances in Urology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-509270
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Atılgan, Doğan& Parlaktas, Bekir Suha& Uluocak, Nihat& Kolukcu, Engin& Erdemir, Fikret& Ozyurt, Huseyin…[et al.]. The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma. Advances in Urology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-509270
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-509270
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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