Rodent Models of Depression : Neurotrophic and Neuroinflammatory Biomarkers
المؤلفون المشاركون
Grigoryan, Grigory
Shishkina, Galina T.
Gulyaeva, Natalia
Stepanichev, Mikhail
Dygalo, Nikolay N.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-05
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Rodent models are an indispensable tool for studying etiology and progress of depression.
Since interrelated systems of neurotrophic factors and cytokines comprise major regulatory mechanisms controlling normal brain plasticity, impairments of these systems form the basis for development of cerebral pathologies, including mental diseases.
The present review focuses on the numerous experimental rodent models of depression induced by different stress factors (exteroceptive and interoceptive) during early life (including prenatal period) or adulthood, giving emphasis to the data on the changes of neurotrophic factors and neuroinflammatory indices in the brain.
These parameters are closely related to behavioral depression-like symptoms and impairments of neuronal plasticity and are both gender- and genotype-dependent.
Stress-related changes in expression of neurotrophins and cytokines in rodent brain are region-specific.
Some contradictory data reported by different groups may be a consequence of differences of stress paradigms or their realization in different laboratories.
Like all experimental models, stress-induced depression-like conditions are experimental simplification of clinical depression states; however, they are suitable for understanding the involvement of neurotrophic factors and cytokines in the pathogenesis of the disease—a goal unachievable in the clinical reality.
These major regulatory systems may be important targets for therapeutic measures as well as for development of drugs for treatment of depression states.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Stepanichev, Mikhail& Dygalo, Nikolay N.& Grigoryan, Grigory& Shishkina, Galina T.& Gulyaeva, Natalia. 2014. Rodent Models of Depression : Neurotrophic and Neuroinflammatory Biomarkers. BioMed Research International،Vol. 2014, no. 2014, pp.1-20.
https://search.emarefa.net/detail/BIM-509314
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Stepanichev, Mikhail…[et al.]. Rodent Models of Depression : Neurotrophic and Neuroinflammatory Biomarkers. BioMed Research International No. 2014 (2014), pp.1-20.
https://search.emarefa.net/detail/BIM-509314
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Stepanichev, Mikhail& Dygalo, Nikolay N.& Grigoryan, Grigory& Shishkina, Galina T.& Gulyaeva, Natalia. Rodent Models of Depression : Neurotrophic and Neuroinflammatory Biomarkers. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-20.
https://search.emarefa.net/detail/BIM-509314
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-509314
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر