Rodent Models of Depression : Neurotrophic and Neuroinflammatory Biomarkers
Joint Authors
Grigoryan, Grigory
Shishkina, Galina T.
Gulyaeva, Natalia
Stepanichev, Mikhail
Dygalo, Nikolay N.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-05
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Rodent models are an indispensable tool for studying etiology and progress of depression.
Since interrelated systems of neurotrophic factors and cytokines comprise major regulatory mechanisms controlling normal brain plasticity, impairments of these systems form the basis for development of cerebral pathologies, including mental diseases.
The present review focuses on the numerous experimental rodent models of depression induced by different stress factors (exteroceptive and interoceptive) during early life (including prenatal period) or adulthood, giving emphasis to the data on the changes of neurotrophic factors and neuroinflammatory indices in the brain.
These parameters are closely related to behavioral depression-like symptoms and impairments of neuronal plasticity and are both gender- and genotype-dependent.
Stress-related changes in expression of neurotrophins and cytokines in rodent brain are region-specific.
Some contradictory data reported by different groups may be a consequence of differences of stress paradigms or their realization in different laboratories.
Like all experimental models, stress-induced depression-like conditions are experimental simplification of clinical depression states; however, they are suitable for understanding the involvement of neurotrophic factors and cytokines in the pathogenesis of the disease—a goal unachievable in the clinical reality.
These major regulatory systems may be important targets for therapeutic measures as well as for development of drugs for treatment of depression states.
American Psychological Association (APA)
Stepanichev, Mikhail& Dygalo, Nikolay N.& Grigoryan, Grigory& Shishkina, Galina T.& Gulyaeva, Natalia. 2014. Rodent Models of Depression : Neurotrophic and Neuroinflammatory Biomarkers. BioMed Research International،Vol. 2014, no. 2014, pp.1-20.
https://search.emarefa.net/detail/BIM-509314
Modern Language Association (MLA)
Stepanichev, Mikhail…[et al.]. Rodent Models of Depression : Neurotrophic and Neuroinflammatory Biomarkers. BioMed Research International No. 2014 (2014), pp.1-20.
https://search.emarefa.net/detail/BIM-509314
American Medical Association (AMA)
Stepanichev, Mikhail& Dygalo, Nikolay N.& Grigoryan, Grigory& Shishkina, Galina T.& Gulyaeva, Natalia. Rodent Models of Depression : Neurotrophic and Neuroinflammatory Biomarkers. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-20.
https://search.emarefa.net/detail/BIM-509314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509314