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Tumor and the Microenvironment : A Chance to Reframe the Paradigm of Carcinogenesis?
المؤلفون المشاركون
Cucina, Alessandra
Bizzarri, Mariano
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The somatic mutation theory of carcinogenesis has eventually accumulated an impressive body of shortfalls and paradoxes, as admittedly claimed by its own supporters given that the cell-based approach can hardly explain the emergence of tissue-based processes, like cancer.
However, experimental data and alternatives theories developed during the last decades may actually provide a new framework on which cancer research should be reframed.
Such issue may be fulfilled embracing new theoretical perspectives, taking the cells-microenvironment interplay as the privileged level of observation and assuming radically different premises as well as new methodological frameworks.
Within that perspective, the tumor microenvironment cannot be merely considered akin to new “factor” to be added to an already long list of “signaling factors”; microenvironment represents the physical-biochemical support of the morphogenetic field which drives epithelial cells towards differentiation and phenotype transformation, according to rules understandable only by means of a systems biology approach.
That endeavour entails three fundamental aspects: general biological premises, the level of observation (i.e., the systems to which we are looking for), and the principles of biological organization that would help in integrating and understanding experimental data.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bizzarri, Mariano& Cucina, Alessandra. 2014. Tumor and the Microenvironment : A Chance to Reframe the Paradigm of Carcinogenesis?. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-509342
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bizzarri, Mariano& Cucina, Alessandra. Tumor and the Microenvironment : A Chance to Reframe the Paradigm of Carcinogenesis?. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-509342
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bizzarri, Mariano& Cucina, Alessandra. Tumor and the Microenvironment : A Chance to Reframe the Paradigm of Carcinogenesis?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-509342
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-509342
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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