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Tumor and the Microenvironment : A Chance to Reframe the Paradigm of Carcinogenesis?
Joint Authors
Cucina, Alessandra
Bizzarri, Mariano
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The somatic mutation theory of carcinogenesis has eventually accumulated an impressive body of shortfalls and paradoxes, as admittedly claimed by its own supporters given that the cell-based approach can hardly explain the emergence of tissue-based processes, like cancer.
However, experimental data and alternatives theories developed during the last decades may actually provide a new framework on which cancer research should be reframed.
Such issue may be fulfilled embracing new theoretical perspectives, taking the cells-microenvironment interplay as the privileged level of observation and assuming radically different premises as well as new methodological frameworks.
Within that perspective, the tumor microenvironment cannot be merely considered akin to new “factor” to be added to an already long list of “signaling factors”; microenvironment represents the physical-biochemical support of the morphogenetic field which drives epithelial cells towards differentiation and phenotype transformation, according to rules understandable only by means of a systems biology approach.
That endeavour entails three fundamental aspects: general biological premises, the level of observation (i.e., the systems to which we are looking for), and the principles of biological organization that would help in integrating and understanding experimental data.
American Psychological Association (APA)
Bizzarri, Mariano& Cucina, Alessandra. 2014. Tumor and the Microenvironment : A Chance to Reframe the Paradigm of Carcinogenesis?. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-509342
Modern Language Association (MLA)
Bizzarri, Mariano& Cucina, Alessandra. Tumor and the Microenvironment : A Chance to Reframe the Paradigm of Carcinogenesis?. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-509342
American Medical Association (AMA)
Bizzarri, Mariano& Cucina, Alessandra. Tumor and the Microenvironment : A Chance to Reframe the Paradigm of Carcinogenesis?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-509342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509342