Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic dbdb Mice
المؤلفون المشاركون
Heo, Seok Hyun
Ha, Tae Youl
Um, Min Young
Lee, Hyunjung
Ahn, Jiyun
Jung, Chang Hwa
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Eleutheroside E (EE), a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory and protective effects in ischemia heart.
However, it is unknown whether it ameliorates insulin resistance and reduces hyperglycemia in diabetes.
This study investigated the effect of EE-containing ES extracts, as well as EE, on hyperglycemia and insulin resistance in db/db mice.
EE increased the insulin-provoked glucose uptake in C2C12 myotubes.
Moreover, EE improved TNF-α-induced suppression of glucose uptake in 3T3-L1 adipocytes.
Five-week-old db/db mice were fed a diet consisting of ES extract or EE for 5 weeks.
Both were effective in improving serum lipid profiles and significantly decreased blood glucose and serum insulin levels.
ES and EE supplementation effectively attenuated HOMA-IR.
Glucose tolerance and insulin tolerance tests showed that EE increased insulin sensitivity.
Immunohistochemical staining indicated that ES and EE protected pancreatic alpha and beta cells from diabetic damage.
In addition, ES and EE improved hepatic glucose metabolism by upregulating glycolysis and downregulating gluconeogenesis in obese type 2 diabetic mice.
These data suggest that EE mediates the hyperglycemic effects of ES by regulating insulin signaling and glucose utilization.
The beneficial effects of EE may provide an effective and powerful strategy to alleviate diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahn, Jiyun& Um, Min Young& Lee, Hyunjung& Jung, Chang Hwa& Heo, Seok Hyun& Ha, Tae Youl. 2013. Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic dbdb Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-509359
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahn, Jiyun…[et al.]. Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic dbdb Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-509359
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahn, Jiyun& Um, Min Young& Lee, Hyunjung& Jung, Chang Hwa& Heo, Seok Hyun& Ha, Tae Youl. Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic dbdb Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-509359
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-509359
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر