Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic dbdb Mice
Joint Authors
Heo, Seok Hyun
Ha, Tae Youl
Um, Min Young
Lee, Hyunjung
Ahn, Jiyun
Jung, Chang Hwa
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Eleutheroside E (EE), a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory and protective effects in ischemia heart.
However, it is unknown whether it ameliorates insulin resistance and reduces hyperglycemia in diabetes.
This study investigated the effect of EE-containing ES extracts, as well as EE, on hyperglycemia and insulin resistance in db/db mice.
EE increased the insulin-provoked glucose uptake in C2C12 myotubes.
Moreover, EE improved TNF-α-induced suppression of glucose uptake in 3T3-L1 adipocytes.
Five-week-old db/db mice were fed a diet consisting of ES extract or EE for 5 weeks.
Both were effective in improving serum lipid profiles and significantly decreased blood glucose and serum insulin levels.
ES and EE supplementation effectively attenuated HOMA-IR.
Glucose tolerance and insulin tolerance tests showed that EE increased insulin sensitivity.
Immunohistochemical staining indicated that ES and EE protected pancreatic alpha and beta cells from diabetic damage.
In addition, ES and EE improved hepatic glucose metabolism by upregulating glycolysis and downregulating gluconeogenesis in obese type 2 diabetic mice.
These data suggest that EE mediates the hyperglycemic effects of ES by regulating insulin signaling and glucose utilization.
The beneficial effects of EE may provide an effective and powerful strategy to alleviate diabetes.
American Psychological Association (APA)
Ahn, Jiyun& Um, Min Young& Lee, Hyunjung& Jung, Chang Hwa& Heo, Seok Hyun& Ha, Tae Youl. 2013. Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic dbdb Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-509359
Modern Language Association (MLA)
Ahn, Jiyun…[et al.]. Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic dbdb Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-509359
American Medical Association (AMA)
Ahn, Jiyun& Um, Min Young& Lee, Hyunjung& Jung, Chang Hwa& Heo, Seok Hyun& Ha, Tae Youl. Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic dbdb Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-509359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509359