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Interaction between Overtraining and the Interindividual Variability May (Not) Trigger Muscle Oxidative Stress and Cardiomyocyte Apoptosis in Rats
المؤلفون المشاركون
Buscariolli de Oliveira, Renato
Damas, Danilo
Ferraresso, Rodrigo Luiz Perroni
Hohl, Rodrigo
Brenzikofer, René
Nunes, Lázaro Alessandro Soares
Macedo, Denise Vaz
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Severe endurance training (overtraining) may cause underperformance related to muscle oxidative stress and cardiomyocyte alterations.
Currently, such relationship has not been empirically established.
In this study, Wistar rats (n=19) underwent eight weeks of daily exercise sessions followed by three overtraining weeks in which the daily frequency of exercise sessions increased.
After the 11th training week, eight rats exhibited a reduction of 38% in performance (nonfunctional overreaching group (NFOR)), whereas eleven rats exhibited an increase of 18% in performance (functional overreaching group (FOR)).
The red gastrocnemius of NFOR presented significantly lower citrate synthase activity compared to FOR, but similar to that of the control.
The activity of mitochondrial complex IV in NFOR was lower than that of the control and FOR.
This impaired mitochondrial adaptation in NFOR was associated with increased antioxidant enzyme activities and increased lipid peroxidation (in muscle and plasma) relative to FOR and control.
Cardiomyocyte apoptosis was higher in NFOR.
Plasma creatine kinase levels were unchanged.
We observed that some rats that presented evidence of muscle oxidative stress are also subject to cardiomyocyte apoptosis under endurance overtraining.
Blood lipid peroxides may be a suitable biomarker for muscle oxidative stress that is unrelated to severe muscle damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ferraresso, Rodrigo Luiz Perroni& Buscariolli de Oliveira, Renato& Macedo, Denise Vaz& Nunes, Lázaro Alessandro Soares& Brenzikofer, René& Damas, Danilo…[et al.]. 2012. Interaction between Overtraining and the Interindividual Variability May (Not) Trigger Muscle Oxidative Stress and Cardiomyocyte Apoptosis in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-509492
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ferraresso, Rodrigo Luiz Perroni…[et al.]. Interaction between Overtraining and the Interindividual Variability May (Not) Trigger Muscle Oxidative Stress and Cardiomyocyte Apoptosis in Rats. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-509492
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ferraresso, Rodrigo Luiz Perroni& Buscariolli de Oliveira, Renato& Macedo, Denise Vaz& Nunes, Lázaro Alessandro Soares& Brenzikofer, René& Damas, Danilo…[et al.]. Interaction between Overtraining and the Interindividual Variability May (Not) Trigger Muscle Oxidative Stress and Cardiomyocyte Apoptosis in Rats. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-509492
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-509492
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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