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Germinoma with Involvement of Midline and Off-Midline Intracranial Structures
المؤلفون المشاركون
Loto, Monica Graciela
González Abbati, Santiago
Misiunas, Alejandro
Torino, Rafael
Danilowicz, Karina
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-09
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Germinomas are malignant intracranial germ tumors, usually found in suprasellar regions.
Less than 10% are localized in off-middle structures, and synchronous involvement of both structures has only exceptionally been published.
A case of an 18-year-old male patient with progressive right-sided hemiparesis and panhypopituitarism was reviewed.
Brain MRI showed a solid mass involving pituitary and hypothalamus with thickening of pituitary stalk, high intensity lesions on T2-weighted imaging in left internal capsule, caudate nucleus, globus pallidus, and mild atrophy of the left internal capsule and cerebral peduncle.
Nonadenomatous lesions were considered in the differential diagnosis.
Alfa-fetoprotein (AFP) levels were negative in both serum and cerebrospinal fluid (CSF), while β-human chorionic gonadotrophin (β-HCG) levels were slightly increased in CSF.
A transsphenoidal biopsy identified a germinoma.
Four cycles of chemotherapy with bleomicine, etoposide, and cysplatin were given, followed by radiotherapy, but patients died due to a recidiva.
Conclusion.
Germinoma must be considered in patients with insipidus diabetes with a sellar mass with thickening of pituitary stalk; and ectopic germinoma must be suspected in patients with slowly progressive hemiparesis with cerebral hemiatrophy.
Even with a rare condition, colocalization of midline and off-midline germinoma must be suspected in the presence of these typical signs of both localizations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Loto, Monica Graciela& Danilowicz, Karina& González Abbati, Santiago& Torino, Rafael& Misiunas, Alejandro. 2014. Germinoma with Involvement of Midline and Off-Midline Intracranial Structures. Case Reports in Endocrinology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-509614
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Loto, Monica Graciela…[et al.]. Germinoma with Involvement of Midline and Off-Midline Intracranial Structures. Case Reports in Endocrinology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-509614
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Loto, Monica Graciela& Danilowicz, Karina& González Abbati, Santiago& Torino, Rafael& Misiunas, Alejandro. Germinoma with Involvement of Midline and Off-Midline Intracranial Structures. Case Reports in Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-509614
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-509614
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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