Germinoma with Involvement of Midline and Off-Midline Intracranial Structures
Joint Authors
Loto, Monica Graciela
González Abbati, Santiago
Misiunas, Alejandro
Torino, Rafael
Danilowicz, Karina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Germinomas are malignant intracranial germ tumors, usually found in suprasellar regions.
Less than 10% are localized in off-middle structures, and synchronous involvement of both structures has only exceptionally been published.
A case of an 18-year-old male patient with progressive right-sided hemiparesis and panhypopituitarism was reviewed.
Brain MRI showed a solid mass involving pituitary and hypothalamus with thickening of pituitary stalk, high intensity lesions on T2-weighted imaging in left internal capsule, caudate nucleus, globus pallidus, and mild atrophy of the left internal capsule and cerebral peduncle.
Nonadenomatous lesions were considered in the differential diagnosis.
Alfa-fetoprotein (AFP) levels were negative in both serum and cerebrospinal fluid (CSF), while β-human chorionic gonadotrophin (β-HCG) levels were slightly increased in CSF.
A transsphenoidal biopsy identified a germinoma.
Four cycles of chemotherapy with bleomicine, etoposide, and cysplatin were given, followed by radiotherapy, but patients died due to a recidiva.
Conclusion.
Germinoma must be considered in patients with insipidus diabetes with a sellar mass with thickening of pituitary stalk; and ectopic germinoma must be suspected in patients with slowly progressive hemiparesis with cerebral hemiatrophy.
Even with a rare condition, colocalization of midline and off-midline germinoma must be suspected in the presence of these typical signs of both localizations.
American Psychological Association (APA)
Loto, Monica Graciela& Danilowicz, Karina& González Abbati, Santiago& Torino, Rafael& Misiunas, Alejandro. 2014. Germinoma with Involvement of Midline and Off-Midline Intracranial Structures. Case Reports in Endocrinology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-509614
Modern Language Association (MLA)
Loto, Monica Graciela…[et al.]. Germinoma with Involvement of Midline and Off-Midline Intracranial Structures. Case Reports in Endocrinology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-509614
American Medical Association (AMA)
Loto, Monica Graciela& Danilowicz, Karina& González Abbati, Santiago& Torino, Rafael& Misiunas, Alejandro. Germinoma with Involvement of Midline and Off-Midline Intracranial Structures. Case Reports in Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-509614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509614