Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant Species Mitracarpus frigidus on Adult Schistosoma mansoni Worms
المؤلفون المشاركون
Mattos, Ana Carolina Alves
Pinto, Nícolas de Castro Campos
Pinto, Priscila de Faria
Vasconcelos, Eveline Gomes
Aragão, Danielle Maria de Oliveira
Florêncio, Jônatas Rodrigues
Coelho, Paulo Marcos Zech
Castañon, Maria Christina Marques Nogueira
Fabri, Rodrigo Luiz
Scio, Elita
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The aims of this work were to evaluate the in vitro and in vivo schistosomicidal properties of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and to determine its HPLC profile.
For the in vitro experiment, four pairs of adult worms, obtained from infected mice, were exposed to different concentrations of MFM (100 to 400 μg/mL) for 24 and 48 h and analyzed under an inverted microscope.
For the in vivo experiment, mice were inoculated with cercariae and, 20 days after infection, MFM (100 and 300 mg/kg) was administered orally for the following 25 days.
Mice were euthanized after 60 days.
MFM showed in vitro schistosomicidal activity, exhibiting the opening of the gynaecophoral canal of some male schistosomes, the presence of contorted muscles, vesicles, and the darkening of the paired worms skin.
In vivo experiments showed that MFM treatments significantly reduced total worm count, as praziquantel, showing a decrease in liver and spleen weight.
Also, a significant reduction in granuloma density was observed.
MFM treatment did not cause alterations in the liver function of either infected or noninfected mice.
The HPLC chromatogram profile showed the presence of kaempferol-O-rutinoside, rutin, kaempferol, psychorubrin, and ursolic acid.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fabri, Rodrigo Luiz& Aragão, Danielle Maria de Oliveira& Florêncio, Jônatas Rodrigues& Pinto, Nícolas de Castro Campos& Mattos, Ana Carolina Alves& Coelho, Paulo Marcos Zech…[et al.]. 2014. Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant Species Mitracarpus frigidus on Adult Schistosoma mansoni Worms. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-509998
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fabri, Rodrigo Luiz…[et al.]. Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant Species Mitracarpus frigidus on Adult Schistosoma mansoni Worms. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-509998
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fabri, Rodrigo Luiz& Aragão, Danielle Maria de Oliveira& Florêncio, Jônatas Rodrigues& Pinto, Nícolas de Castro Campos& Mattos, Ana Carolina Alves& Coelho, Paulo Marcos Zech…[et al.]. Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant Species Mitracarpus frigidus on Adult Schistosoma mansoni Worms. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-509998
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-509998
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر