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Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant Species Mitracarpus frigidus on Adult Schistosoma mansoni Worms
Joint Authors
Mattos, Ana Carolina Alves
Pinto, Nícolas de Castro Campos
Pinto, Priscila de Faria
Vasconcelos, Eveline Gomes
Aragão, Danielle Maria de Oliveira
Florêncio, Jônatas Rodrigues
Coelho, Paulo Marcos Zech
Castañon, Maria Christina Marques Nogueira
Fabri, Rodrigo Luiz
Scio, Elita
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aims of this work were to evaluate the in vitro and in vivo schistosomicidal properties of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and to determine its HPLC profile.
For the in vitro experiment, four pairs of adult worms, obtained from infected mice, were exposed to different concentrations of MFM (100 to 400 μg/mL) for 24 and 48 h and analyzed under an inverted microscope.
For the in vivo experiment, mice were inoculated with cercariae and, 20 days after infection, MFM (100 and 300 mg/kg) was administered orally for the following 25 days.
Mice were euthanized after 60 days.
MFM showed in vitro schistosomicidal activity, exhibiting the opening of the gynaecophoral canal of some male schistosomes, the presence of contorted muscles, vesicles, and the darkening of the paired worms skin.
In vivo experiments showed that MFM treatments significantly reduced total worm count, as praziquantel, showing a decrease in liver and spleen weight.
Also, a significant reduction in granuloma density was observed.
MFM treatment did not cause alterations in the liver function of either infected or noninfected mice.
The HPLC chromatogram profile showed the presence of kaempferol-O-rutinoside, rutin, kaempferol, psychorubrin, and ursolic acid.
American Psychological Association (APA)
Fabri, Rodrigo Luiz& Aragão, Danielle Maria de Oliveira& Florêncio, Jônatas Rodrigues& Pinto, Nícolas de Castro Campos& Mattos, Ana Carolina Alves& Coelho, Paulo Marcos Zech…[et al.]. 2014. Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant Species Mitracarpus frigidus on Adult Schistosoma mansoni Worms. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-509998
Modern Language Association (MLA)
Fabri, Rodrigo Luiz…[et al.]. Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant Species Mitracarpus frigidus on Adult Schistosoma mansoni Worms. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-509998
American Medical Association (AMA)
Fabri, Rodrigo Luiz& Aragão, Danielle Maria de Oliveira& Florêncio, Jônatas Rodrigues& Pinto, Nícolas de Castro Campos& Mattos, Ana Carolina Alves& Coelho, Paulo Marcos Zech…[et al.]. Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant Species Mitracarpus frigidus on Adult Schistosoma mansoni Worms. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-509998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509998