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Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma : Relationship with Tumor Stage and Survival after Esophagectomy
المؤلفون المشاركون
Madalosso, Carlos Augusto
Fornari, Fernando
Aita, Lucas
Navarini, Daniel
Meurer, Luise
Gurski, Richard Ricachenevski
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-26
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background and Aims.
Esophageal adenocarcinoma (EA) is an aggressive tumor with increasing incidence in occidental countries.
Several prognostic biomarkers have been proposed, including epidermal growth factor receptor (EGFR).
The aim of this study was to assess whether EGFR expression predicts EA staging and patient survival.
Methods.
In this historical cohort, consecutive patients with EA managed between 2000 and 2010 were considered eligible for the study.
Surgical specimens of patients treated with transhiatal esophagectomy were evaluated to establish EGFR expression and tumor differentiation.
Staging was classified according with tumor-node-metastasis (TNM) system.
Survival was determined according to either medical register or patient’s family contact.
Results.
Thirty-seven patients who underwent esophagectomy without presurgical chemotherapy or radiotherapy were studied.
EGFR expression was found in 16 patients (43%).
EGFR expression was more frequent as higher was the TNM (I and II=0% versus III=47% versus IV=100%; P<0.001).
Average survival in months was significantly shorter in the group of patients with EGFR expression (10.5 versus 21.7; P=0.001).
Conclusions.
In patients with esophageal adenocarcinoma treated with transhiatal esophagectomy, EGFR expression was related to higher TNM staging and shorter survival.
EGFR expression might be assumed as a prognostic marker for esophageal adenocarcinoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Navarini, Daniel& Gurski, Richard Ricachenevski& Madalosso, Carlos Augusto& Aita, Lucas& Meurer, Luise& Fornari, Fernando. 2012. Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma : Relationship with Tumor Stage and Survival after Esophagectomy. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510065
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Navarini, Daniel…[et al.]. Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma : Relationship with Tumor Stage and Survival after Esophagectomy. Gastroenterology Research and Practice No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-510065
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Navarini, Daniel& Gurski, Richard Ricachenevski& Madalosso, Carlos Augusto& Aita, Lucas& Meurer, Luise& Fornari, Fernando. Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma : Relationship with Tumor Stage and Survival after Esophagectomy. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510065
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510065
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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