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Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma : Relationship with Tumor Stage and Survival after Esophagectomy
Joint Authors
Madalosso, Carlos Augusto
Fornari, Fernando
Aita, Lucas
Navarini, Daniel
Meurer, Luise
Gurski, Richard Ricachenevski
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background and Aims.
Esophageal adenocarcinoma (EA) is an aggressive tumor with increasing incidence in occidental countries.
Several prognostic biomarkers have been proposed, including epidermal growth factor receptor (EGFR).
The aim of this study was to assess whether EGFR expression predicts EA staging and patient survival.
Methods.
In this historical cohort, consecutive patients with EA managed between 2000 and 2010 were considered eligible for the study.
Surgical specimens of patients treated with transhiatal esophagectomy were evaluated to establish EGFR expression and tumor differentiation.
Staging was classified according with tumor-node-metastasis (TNM) system.
Survival was determined according to either medical register or patient’s family contact.
Results.
Thirty-seven patients who underwent esophagectomy without presurgical chemotherapy or radiotherapy were studied.
EGFR expression was found in 16 patients (43%).
EGFR expression was more frequent as higher was the TNM (I and II=0% versus III=47% versus IV=100%; P<0.001).
Average survival in months was significantly shorter in the group of patients with EGFR expression (10.5 versus 21.7; P=0.001).
Conclusions.
In patients with esophageal adenocarcinoma treated with transhiatal esophagectomy, EGFR expression was related to higher TNM staging and shorter survival.
EGFR expression might be assumed as a prognostic marker for esophageal adenocarcinoma.
American Psychological Association (APA)
Navarini, Daniel& Gurski, Richard Ricachenevski& Madalosso, Carlos Augusto& Aita, Lucas& Meurer, Luise& Fornari, Fernando. 2012. Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma : Relationship with Tumor Stage and Survival after Esophagectomy. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510065
Modern Language Association (MLA)
Navarini, Daniel…[et al.]. Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma : Relationship with Tumor Stage and Survival after Esophagectomy. Gastroenterology Research and Practice No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-510065
American Medical Association (AMA)
Navarini, Daniel& Gurski, Richard Ricachenevski& Madalosso, Carlos Augusto& Aita, Lucas& Meurer, Luise& Fornari, Fernando. Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma : Relationship with Tumor Stage and Survival after Esophagectomy. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510065