Progression from Excessive to Deficient Syndromes in Chronic Hepatitis B : A Dynamical Network Analysis of miRNA Array Data
المؤلفون المشاركون
Lu, Yi-yu
Zhang, Hui
Zhang, Wei
Su, Shi-Bing
Chen, Qi-long
Song, Ya-Nan
Zhou, Qian-mei
Zhang, Gui-Biao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Traditional Chinese medicine (TCM) treatment is regarded as a safe and effective method for chronic hepatitis B (CHB), which requires a traditional diagnosis method to distinguish the TCM syndrome.
In this study, we study the differences and similarities among excessive, excessive-deficient, and deficient syndromes, by an integrative and comparative analysis of weighted miRNA expression or miRNA-target network in CHB patients.
We first calculated the differential expressed miRNAs based on random module t-test and classified three CHB TCM syndromes using SVM method.
Then, miRNA target genes were obtained by validated database and predicted programs subsequently, the weighted miRNA-target networks were constructed for different TCM syndromes.
Furthermore, prioritize target genes of networks of CHB TCM syndromes progression analyzed using DAVID online analysis.
The results have shown that the difference between TCM syndromes is distinctly based on hierarchical cluster and network structure.
GO and pathway analysis implicated that three CHB syndromes more likely have different molecular mechanisms, while the excessive-deficient and deficient syndromes are more dangerous than excessive syndrome in the process of tumorigenesis.
This study suggested that miRNAs are important mediators for TCM syndromes classification as well as CHB development progression and therefore could be potential diagnosis and therapeutic molecular markers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Qi-long& Lu, Yi-yu& Zhang, Gui-Biao& Song, Ya-Nan& Zhou, Qian-mei& Zhang, Hui…[et al.]. 2013. Progression from Excessive to Deficient Syndromes in Chronic Hepatitis B : A Dynamical Network Analysis of miRNA Array Data. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510277
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Qi-long…[et al.]. Progression from Excessive to Deficient Syndromes in Chronic Hepatitis B : A Dynamical Network Analysis of miRNA Array Data. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-510277
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Qi-long& Lu, Yi-yu& Zhang, Gui-Biao& Song, Ya-Nan& Zhou, Qian-mei& Zhang, Hui…[et al.]. Progression from Excessive to Deficient Syndromes in Chronic Hepatitis B : A Dynamical Network Analysis of miRNA Array Data. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510277
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510277
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر