Progression from Excessive to Deficient Syndromes in Chronic Hepatitis B : A Dynamical Network Analysis of miRNA Array Data
Joint Authors
Lu, Yi-yu
Zhang, Hui
Zhang, Wei
Su, Shi-Bing
Chen, Qi-long
Song, Ya-Nan
Zhou, Qian-mei
Zhang, Gui-Biao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Traditional Chinese medicine (TCM) treatment is regarded as a safe and effective method for chronic hepatitis B (CHB), which requires a traditional diagnosis method to distinguish the TCM syndrome.
In this study, we study the differences and similarities among excessive, excessive-deficient, and deficient syndromes, by an integrative and comparative analysis of weighted miRNA expression or miRNA-target network in CHB patients.
We first calculated the differential expressed miRNAs based on random module t-test and classified three CHB TCM syndromes using SVM method.
Then, miRNA target genes were obtained by validated database and predicted programs subsequently, the weighted miRNA-target networks were constructed for different TCM syndromes.
Furthermore, prioritize target genes of networks of CHB TCM syndromes progression analyzed using DAVID online analysis.
The results have shown that the difference between TCM syndromes is distinctly based on hierarchical cluster and network structure.
GO and pathway analysis implicated that three CHB syndromes more likely have different molecular mechanisms, while the excessive-deficient and deficient syndromes are more dangerous than excessive syndrome in the process of tumorigenesis.
This study suggested that miRNAs are important mediators for TCM syndromes classification as well as CHB development progression and therefore could be potential diagnosis and therapeutic molecular markers.
American Psychological Association (APA)
Chen, Qi-long& Lu, Yi-yu& Zhang, Gui-Biao& Song, Ya-Nan& Zhou, Qian-mei& Zhang, Hui…[et al.]. 2013. Progression from Excessive to Deficient Syndromes in Chronic Hepatitis B : A Dynamical Network Analysis of miRNA Array Data. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510277
Modern Language Association (MLA)
Chen, Qi-long…[et al.]. Progression from Excessive to Deficient Syndromes in Chronic Hepatitis B : A Dynamical Network Analysis of miRNA Array Data. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-510277
American Medical Association (AMA)
Chen, Qi-long& Lu, Yi-yu& Zhang, Gui-Biao& Song, Ya-Nan& Zhou, Qian-mei& Zhang, Hui…[et al.]. Progression from Excessive to Deficient Syndromes in Chronic Hepatitis B : A Dynamical Network Analysis of miRNA Array Data. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510277