Clinical Utility of Ammonia Concentration as a Diagnostic Test in Monitoring of the Treatment with L-Asparaginase in Children with Acute Lymphoblastic Leukemia
المؤلفون المشاركون
Czogała, Małgorzata
Balwierz, Walentyna
Sztefko, Krystyna
Rogatko, Iwona
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
L-asparaginase (ASP) is an enzyme used as one of the basic regimens in the acute lymphoblastic leukemia (ALL) therapy.
Because of the possibility of the enzyme inactivation by antibodies, monitoring of ASP activity is essential.
The aim of the study was to examine if plasma concentration of ammonia, a direct product of the reaction catalyzed by ASP, can be used in the assessment of ASP activity.
A group of 87 patients with acute lymphoblastic leukemia treated in the Department of Pediatric Oncology and Hematology in Krakow was enrolled to the study.
ASP activity and ammonia concentration were measured after ASP administrations during induction.
A positive correlation was found between the ammonia concentration and ASP activity (R=0.44; P<0.0001) and between the medium values of ammonia concentration and ASP activity (R=0.56; P<0.0001).
The analysis of ROC curves revealed the moderate accuracy of the ammonia concentration values in the ASP activity assessment.
It was also found that the medium value of ammonia concentrations can be useful in identification of the patients with low (<100 IU/L) and undetectable (<30 IU/L) ASP activity.
The plasma ammonia concentration may reflect ASP activity and can be useful when a direct measurement of the activity is unavailable.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Czogała, Małgorzata& Balwierz, Walentyna& Sztefko, Krystyna& Rogatko, Iwona. 2014. Clinical Utility of Ammonia Concentration as a Diagnostic Test in Monitoring of the Treatment with L-Asparaginase in Children with Acute Lymphoblastic Leukemia. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-510326
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Czogała, Małgorzata…[et al.]. Clinical Utility of Ammonia Concentration as a Diagnostic Test in Monitoring of the Treatment with L-Asparaginase in Children with Acute Lymphoblastic Leukemia. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-510326
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Czogała, Małgorzata& Balwierz, Walentyna& Sztefko, Krystyna& Rogatko, Iwona. Clinical Utility of Ammonia Concentration as a Diagnostic Test in Monitoring of the Treatment with L-Asparaginase in Children with Acute Lymphoblastic Leukemia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-510326
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510326
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر