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Clinical Utility of Ammonia Concentration as a Diagnostic Test in Monitoring of the Treatment with L-Asparaginase in Children with Acute Lymphoblastic Leukemia
Joint Authors
Czogała, Małgorzata
Balwierz, Walentyna
Sztefko, Krystyna
Rogatko, Iwona
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
L-asparaginase (ASP) is an enzyme used as one of the basic regimens in the acute lymphoblastic leukemia (ALL) therapy.
Because of the possibility of the enzyme inactivation by antibodies, monitoring of ASP activity is essential.
The aim of the study was to examine if plasma concentration of ammonia, a direct product of the reaction catalyzed by ASP, can be used in the assessment of ASP activity.
A group of 87 patients with acute lymphoblastic leukemia treated in the Department of Pediatric Oncology and Hematology in Krakow was enrolled to the study.
ASP activity and ammonia concentration were measured after ASP administrations during induction.
A positive correlation was found between the ammonia concentration and ASP activity (R=0.44; P<0.0001) and between the medium values of ammonia concentration and ASP activity (R=0.56; P<0.0001).
The analysis of ROC curves revealed the moderate accuracy of the ammonia concentration values in the ASP activity assessment.
It was also found that the medium value of ammonia concentrations can be useful in identification of the patients with low (<100 IU/L) and undetectable (<30 IU/L) ASP activity.
The plasma ammonia concentration may reflect ASP activity and can be useful when a direct measurement of the activity is unavailable.
American Psychological Association (APA)
Czogała, Małgorzata& Balwierz, Walentyna& Sztefko, Krystyna& Rogatko, Iwona. 2014. Clinical Utility of Ammonia Concentration as a Diagnostic Test in Monitoring of the Treatment with L-Asparaginase in Children with Acute Lymphoblastic Leukemia. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-510326
Modern Language Association (MLA)
Czogała, Małgorzata…[et al.]. Clinical Utility of Ammonia Concentration as a Diagnostic Test in Monitoring of the Treatment with L-Asparaginase in Children with Acute Lymphoblastic Leukemia. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-510326
American Medical Association (AMA)
Czogała, Małgorzata& Balwierz, Walentyna& Sztefko, Krystyna& Rogatko, Iwona. Clinical Utility of Ammonia Concentration as a Diagnostic Test in Monitoring of the Treatment with L-Asparaginase in Children with Acute Lymphoblastic Leukemia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-510326
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510326