Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications
المؤلفون المشاركون
Raghunathan, Suchi
Tank, Pratik
Patel, Bhoomika
Bhadada, Shraddha
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We have evaluated the effect of buspirone (1.5 mg/kg/day, p.o.) type 1 diabetes induced cardiovascular complications induced by streptozotocin (STZ, 45 mg/kg, i.v.) in Wistar rats.
Various biochemical, cardiovascular, and hemodynamic parameters were measured at the end of 8 weeks of treatment.
STZ produced significant hyperglycaemia, hypoinsulinemia, and dyslipidemia, which was prevented by buspirone treatment.
STZ produced increase in serum creatinine, urea, lactate dehydrogenase, creatinine kinase, and C-reactive protein levels and treatment with buspirone produced reduction in these levels.
STZ produced increase in cardiac and LV hypertrophy index, LV/RV ratio, and LV collagen, which were decreased by buspirone treatment.
Buspirone also prevented STZ induced hemodynamic alterations and oxidative stress.
These results were further supported by histopathological studies in which buspirone showed marked reduction in fibrosis and cardiac fiber disarray.
In conclusion, our data suggests that buspirone is beneficial as an antidiabetic agent in type 1 diabetes mellitus and also prevents its cardiac complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Raghunathan, Suchi& Tank, Pratik& Bhadada, Shraddha& Patel, Bhoomika. 2014. Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-510569
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Raghunathan, Suchi…[et al.]. Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-510569
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Raghunathan, Suchi& Tank, Pratik& Bhadada, Shraddha& Patel, Bhoomika. Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-510569
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510569
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر