Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications
Joint Authors
Raghunathan, Suchi
Tank, Pratik
Patel, Bhoomika
Bhadada, Shraddha
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We have evaluated the effect of buspirone (1.5 mg/kg/day, p.o.) type 1 diabetes induced cardiovascular complications induced by streptozotocin (STZ, 45 mg/kg, i.v.) in Wistar rats.
Various biochemical, cardiovascular, and hemodynamic parameters were measured at the end of 8 weeks of treatment.
STZ produced significant hyperglycaemia, hypoinsulinemia, and dyslipidemia, which was prevented by buspirone treatment.
STZ produced increase in serum creatinine, urea, lactate dehydrogenase, creatinine kinase, and C-reactive protein levels and treatment with buspirone produced reduction in these levels.
STZ produced increase in cardiac and LV hypertrophy index, LV/RV ratio, and LV collagen, which were decreased by buspirone treatment.
Buspirone also prevented STZ induced hemodynamic alterations and oxidative stress.
These results were further supported by histopathological studies in which buspirone showed marked reduction in fibrosis and cardiac fiber disarray.
In conclusion, our data suggests that buspirone is beneficial as an antidiabetic agent in type 1 diabetes mellitus and also prevents its cardiac complications.
American Psychological Association (APA)
Raghunathan, Suchi& Tank, Pratik& Bhadada, Shraddha& Patel, Bhoomika. 2014. Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-510569
Modern Language Association (MLA)
Raghunathan, Suchi…[et al.]. Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-510569
American Medical Association (AMA)
Raghunathan, Suchi& Tank, Pratik& Bhadada, Shraddha& Patel, Bhoomika. Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-510569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510569