Partial Replacement with Menhaden Oil Improves Peripheral Neuropathy in High-Fat-Fed Low-Dose Streptozotocin Type 2 Diabetic Rat
المؤلفون المشاركون
Yorek, Mark A.
Holmes, Amey
Davidson, Eric P.
Coppey, Lawrence J.
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
To determine the effect of partial replacement of a high-fat diet with menhaden oil on diabetic neuropathy in an animal model of type 2 diabetes.
Materials and Methods.
High-fat/low-dose streptozotocin diabetic rats were used to examine the influence of replacing 50% of the source of the high-fat diet (lard) with menhaden oil, a natural source of n-3 fatty acids, on diabetic neuropathy.
Endpoints included analyses of glucose tolerance, fatty liver disease, serum and liver fatty acid composition, serum lipid and adiponectin levels, motor and sensory nerve conduction velocity, thermal sensitivity and innervation of the hindpaw.
Results.
Diabetic rats were insulin resistant and menhaden oil did not improve whole animal glucose utilization.
Menhaden oil did not improve elevated HbA1C levels or serum lipid levels but serum levels of adiponectin were significantly increased and hepatic steatosis was significantly improved.
Diabetic rats were thermal hypoalgesic, had reduced motor and sensory nerve conduction velocities and intraepidermal nerve fiber profiles were decreased in the hindpaw and these endpoints were significantly improved with menhaden oil.
Conclusions.
We found that enrichment of a high-fat diet with menhaden oil improved a number of endpoints associated with diabetic neuropathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Coppey, Lawrence J.& Holmes, Amey& Davidson, Eric P.& Yorek, Mark A.. 2012. Partial Replacement with Menhaden Oil Improves Peripheral Neuropathy in High-Fat-Fed Low-Dose Streptozotocin Type 2 Diabetic Rat. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-510751
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Coppey, Lawrence J.…[et al.]. Partial Replacement with Menhaden Oil Improves Peripheral Neuropathy in High-Fat-Fed Low-Dose Streptozotocin Type 2 Diabetic Rat. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-510751
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Coppey, Lawrence J.& Holmes, Amey& Davidson, Eric P.& Yorek, Mark A.. Partial Replacement with Menhaden Oil Improves Peripheral Neuropathy in High-Fat-Fed Low-Dose Streptozotocin Type 2 Diabetic Rat. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-510751
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510751
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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