Joint Symptoms, Aromatase Inhibitor-Related Adverse Reactions, Are Indirectly Associated with Decreased Serum Estradiol
المؤلفون المشاركون
Nagao, Taeko
Takahashi, Masako
Kanematsu, Miyuki
Tangoku, Akira
Honda, Junko
Sasa, Mitsunori
Nakagawa, Misako
المصدر
International Journal of Surgical Oncology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-05-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Joint symptoms (JSs) are problematic adverse drug reactions (ADRs) of aromatase inhibitors (AIs).
Involvement of decreased serum estradiol (SE) has been suggested.
Patients and Methods.
104 postmenopausal breast cancer patients administered an AI were prospectively investigated regarding various clinical parameters, JS and hot flashes as ADRs, and the SE level.
Results.
JS manifested in 31.7% of patients and hot flashes in 18.3%.
Chi-square testing showed a significantly higher incidence of JS in several patient strata: <55 years old, decreased SE, and elevated total cholesterol (TC).
In univariate analysis, JS correlated significantly with a pre-AI % YAM of ≥80%, decreased SE, and elevated TC.
Eight (7.7%) patients maintained SE at ≥5 pg/mL for >6 consecutive months, with no JS.
In chi-square testing, hot flashes showed a significantly higher incidence in patients <55 years old.
Conclusion.
AI-ADRs occurred more readily in younger patients.
Decreased SE may be indirectly involved in JS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Honda, Junko& Kanematsu, Miyuki& Nakagawa, Misako& Takahashi, Masako& Nagao, Taeko& Tangoku, Akira…[et al.]. 2011. Joint Symptoms, Aromatase Inhibitor-Related Adverse Reactions, Are Indirectly Associated with Decreased Serum Estradiol. International Journal of Surgical Oncology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-510825
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Honda, Junko…[et al.]. Joint Symptoms, Aromatase Inhibitor-Related Adverse Reactions, Are Indirectly Associated with Decreased Serum Estradiol. International Journal of Surgical Oncology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-510825
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Honda, Junko& Kanematsu, Miyuki& Nakagawa, Misako& Takahashi, Masako& Nagao, Taeko& Tangoku, Akira…[et al.]. Joint Symptoms, Aromatase Inhibitor-Related Adverse Reactions, Are Indirectly Associated with Decreased Serum Estradiol. International Journal of Surgical Oncology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-510825
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510825
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر