Joint Symptoms, Aromatase Inhibitor-Related Adverse Reactions, Are Indirectly Associated with Decreased Serum Estradiol
Joint Authors
Nagao, Taeko
Takahashi, Masako
Kanematsu, Miyuki
Tangoku, Akira
Honda, Junko
Sasa, Mitsunori
Nakagawa, Misako
Source
International Journal of Surgical Oncology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Joint symptoms (JSs) are problematic adverse drug reactions (ADRs) of aromatase inhibitors (AIs).
Involvement of decreased serum estradiol (SE) has been suggested.
Patients and Methods.
104 postmenopausal breast cancer patients administered an AI were prospectively investigated regarding various clinical parameters, JS and hot flashes as ADRs, and the SE level.
Results.
JS manifested in 31.7% of patients and hot flashes in 18.3%.
Chi-square testing showed a significantly higher incidence of JS in several patient strata: <55 years old, decreased SE, and elevated total cholesterol (TC).
In univariate analysis, JS correlated significantly with a pre-AI % YAM of ≥80%, decreased SE, and elevated TC.
Eight (7.7%) patients maintained SE at ≥5 pg/mL for >6 consecutive months, with no JS.
In chi-square testing, hot flashes showed a significantly higher incidence in patients <55 years old.
Conclusion.
AI-ADRs occurred more readily in younger patients.
Decreased SE may be indirectly involved in JS.
American Psychological Association (APA)
Honda, Junko& Kanematsu, Miyuki& Nakagawa, Misako& Takahashi, Masako& Nagao, Taeko& Tangoku, Akira…[et al.]. 2011. Joint Symptoms, Aromatase Inhibitor-Related Adverse Reactions, Are Indirectly Associated with Decreased Serum Estradiol. International Journal of Surgical Oncology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-510825
Modern Language Association (MLA)
Honda, Junko…[et al.]. Joint Symptoms, Aromatase Inhibitor-Related Adverse Reactions, Are Indirectly Associated with Decreased Serum Estradiol. International Journal of Surgical Oncology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-510825
American Medical Association (AMA)
Honda, Junko& Kanematsu, Miyuki& Nakagawa, Misako& Takahashi, Masako& Nagao, Taeko& Tangoku, Akira…[et al.]. Joint Symptoms, Aromatase Inhibitor-Related Adverse Reactions, Are Indirectly Associated with Decreased Serum Estradiol. International Journal of Surgical Oncology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-510825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510825