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Plasma Disposition of Conventional and Long-Acting Moxifloxacin in Sheep after Intravenous Administration
المؤلفون المشاركون
Mody, Shailesh K.
Modi, C. M.
Patel, Hitesh B.
Modi, F. D.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-29
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
This study describes disposition of long-acting moxifloxacin and conventional formulations of moxifloxacin in sheep after intravenous administration in five male sheep.
Long acting moxifloxacin solution (10% moxifloxacin in solution with L-arginine, N-butyl alcohol, and benzyl alcohol) and conventional moxifloxacin (10%) were injected in jugular vein.
Blood samples were collected from contralateral jugular vein in test tubes containing 30–50 IU heparin (anticoagulant) periodically from 0.083 to 72 h of drug administration.
Drug concentrations in plasma were determined using High-Performance Liquid Chromatography (HPLC) with fluorescence detector.
The mobile phase consisted of a mixture of buffer (10 gm of tetrabutyl ammonium hydrogen sulphate per liter-deionised water) and acetonitrile (80 : 20).
The buffer was 0.067M of disodium hydrogen phosphate with pH of 7.5.
The flow rate was 1 mL·min−1 at ambient temperature.
The effluent was monitored at 296 nm excitation and 504 nm emissions wavelength.
HPLC with fluorescence detector method for plasma moxifloxacin assay was standardized with specific modification for plasma of sheep in the present study.
After single-dose intravenous administration of long acting moxifloxacin the plasma concentration of 0.016 ± 0.001 μg·mL−1 was maintained for up to 72 h.
Conventional formulation of moxifloxacin remained in body for up to 24 h of drug administration with the level of 0.015 ± 0.005 μg·mL−1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Modi, C. M.& Mody, Shailesh K.& Modi, F. D.& Patel, Hitesh B.. 2012. Plasma Disposition of Conventional and Long-Acting Moxifloxacin in Sheep after Intravenous Administration. ISRN Veterinary Science،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-510833
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Modi, C. M.…[et al.]. Plasma Disposition of Conventional and Long-Acting Moxifloxacin in Sheep after Intravenous Administration. ISRN Veterinary Science No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-510833
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Modi, C. M.& Mody, Shailesh K.& Modi, F. D.& Patel, Hitesh B.. Plasma Disposition of Conventional and Long-Acting Moxifloxacin in Sheep after Intravenous Administration. ISRN Veterinary Science. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-510833
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510833
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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