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Plasma Disposition of Conventional and Long-Acting Moxifloxacin in Sheep after Intravenous Administration
Joint Authors
Mody, Shailesh K.
Modi, C. M.
Patel, Hitesh B.
Modi, F. D.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-29
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
This study describes disposition of long-acting moxifloxacin and conventional formulations of moxifloxacin in sheep after intravenous administration in five male sheep.
Long acting moxifloxacin solution (10% moxifloxacin in solution with L-arginine, N-butyl alcohol, and benzyl alcohol) and conventional moxifloxacin (10%) were injected in jugular vein.
Blood samples were collected from contralateral jugular vein in test tubes containing 30–50 IU heparin (anticoagulant) periodically from 0.083 to 72 h of drug administration.
Drug concentrations in plasma were determined using High-Performance Liquid Chromatography (HPLC) with fluorescence detector.
The mobile phase consisted of a mixture of buffer (10 gm of tetrabutyl ammonium hydrogen sulphate per liter-deionised water) and acetonitrile (80 : 20).
The buffer was 0.067M of disodium hydrogen phosphate with pH of 7.5.
The flow rate was 1 mL·min−1 at ambient temperature.
The effluent was monitored at 296 nm excitation and 504 nm emissions wavelength.
HPLC with fluorescence detector method for plasma moxifloxacin assay was standardized with specific modification for plasma of sheep in the present study.
After single-dose intravenous administration of long acting moxifloxacin the plasma concentration of 0.016 ± 0.001 μg·mL−1 was maintained for up to 72 h.
Conventional formulation of moxifloxacin remained in body for up to 24 h of drug administration with the level of 0.015 ± 0.005 μg·mL−1.
American Psychological Association (APA)
Modi, C. M.& Mody, Shailesh K.& Modi, F. D.& Patel, Hitesh B.. 2012. Plasma Disposition of Conventional and Long-Acting Moxifloxacin in Sheep after Intravenous Administration. ISRN Veterinary Science،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-510833
Modern Language Association (MLA)
Modi, C. M.…[et al.]. Plasma Disposition of Conventional and Long-Acting Moxifloxacin in Sheep after Intravenous Administration. ISRN Veterinary Science No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-510833
American Medical Association (AMA)
Modi, C. M.& Mody, Shailesh K.& Modi, F. D.& Patel, Hitesh B.. Plasma Disposition of Conventional and Long-Acting Moxifloxacin in Sheep after Intravenous Administration. ISRN Veterinary Science. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-510833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510833