Mitochondria DeathSurvival Signaling Pathways in Cardiotoxicity Induced by Anthracyclines and Anticancer-Targeted Therapies
المؤلفون المشاركون
Neviere, Remi
Hurt, Christopher
Montaigne, David
المصدر
Biochemistry Research International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Anthracyclines remain the cornerstone of treatment in many malignancies but these agents have a cumulative dose relationship with cardiotoxicity.
Development of cardiomyopathy and congestive heart failure induced by anthracyclines are typically dose-dependent, irreversible, and cumulative.
Although past studies of cardiotoxicity have focused on anthracyclines, more recently interest has turned to anticancer drugs that target many proteins kinases, such as tyrosine kinases.
An attractive model to explain the mechanism of this cardiotoxicity could be myocyte loss through cell death pathways.
Inhibition of mitochondrial transition permeability is a valuable tool to prevent doxorubicin-induced cardiotoxicity.
In response to anthracycline treatment, activation of several protein kinases, neuregulin/ErbB2 signaling, and transcriptional factors modify mitochondrial functions that determine cell death or survival through the modulation of mitochondrial membrane permeability.
Cellular response to anthracyclines is also modulated by a myriad of transcriptional factors that influence cell fate.
Several novel targeted chemotherapeutic agents have been associated with a small but worrying risk of left ventricular dysfunction.
Agents such as trastuzumab and tyrosine kinase inhibitors can lead to cardiotoxicity that is fundamentally different from that caused by anthracyclines, whereas biological effects converge to the mitochondria as a critical target.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Montaigne, David& Hurt, Christopher& Neviere, Remi. 2012. Mitochondria DeathSurvival Signaling Pathways in Cardiotoxicity Induced by Anthracyclines and Anticancer-Targeted Therapies. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-510859
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Montaigne, David…[et al.]. Mitochondria DeathSurvival Signaling Pathways in Cardiotoxicity Induced by Anthracyclines and Anticancer-Targeted Therapies. Biochemistry Research International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-510859
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Montaigne, David& Hurt, Christopher& Neviere, Remi. Mitochondria DeathSurvival Signaling Pathways in Cardiotoxicity Induced by Anthracyclines and Anticancer-Targeted Therapies. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-510859
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510859
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر