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Mitochondria DeathSurvival Signaling Pathways in Cardiotoxicity Induced by Anthracyclines and Anticancer-Targeted Therapies
Joint Authors
Neviere, Remi
Hurt, Christopher
Montaigne, David
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Anthracyclines remain the cornerstone of treatment in many malignancies but these agents have a cumulative dose relationship with cardiotoxicity.
Development of cardiomyopathy and congestive heart failure induced by anthracyclines are typically dose-dependent, irreversible, and cumulative.
Although past studies of cardiotoxicity have focused on anthracyclines, more recently interest has turned to anticancer drugs that target many proteins kinases, such as tyrosine kinases.
An attractive model to explain the mechanism of this cardiotoxicity could be myocyte loss through cell death pathways.
Inhibition of mitochondrial transition permeability is a valuable tool to prevent doxorubicin-induced cardiotoxicity.
In response to anthracycline treatment, activation of several protein kinases, neuregulin/ErbB2 signaling, and transcriptional factors modify mitochondrial functions that determine cell death or survival through the modulation of mitochondrial membrane permeability.
Cellular response to anthracyclines is also modulated by a myriad of transcriptional factors that influence cell fate.
Several novel targeted chemotherapeutic agents have been associated with a small but worrying risk of left ventricular dysfunction.
Agents such as trastuzumab and tyrosine kinase inhibitors can lead to cardiotoxicity that is fundamentally different from that caused by anthracyclines, whereas biological effects converge to the mitochondria as a critical target.
American Psychological Association (APA)
Montaigne, David& Hurt, Christopher& Neviere, Remi. 2012. Mitochondria DeathSurvival Signaling Pathways in Cardiotoxicity Induced by Anthracyclines and Anticancer-Targeted Therapies. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-510859
Modern Language Association (MLA)
Montaigne, David…[et al.]. Mitochondria DeathSurvival Signaling Pathways in Cardiotoxicity Induced by Anthracyclines and Anticancer-Targeted Therapies. Biochemistry Research International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-510859
American Medical Association (AMA)
Montaigne, David& Hurt, Christopher& Neviere, Remi. Mitochondria DeathSurvival Signaling Pathways in Cardiotoxicity Induced by Anthracyclines and Anticancer-Targeted Therapies. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-510859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510859