Immunorecognition of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Some Normal and Malignant Tissues from Genitourinary System

المؤلفون المشاركون

Calzado, Enrique Rengifo
Cedeño, Mercedes
Carr, Adriana
Alvarez, Rosa Irene
Rengifo, Charles E.
Blanco, Rancés
Frómeta, Milagros
Escobar, Xiomara
Blanco, Damián

المصدر

ISRN Pathology

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-10-05

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

N-glycolyl neuraminic acid has been considered as a tumour-associated antigen forming both glycolipid and glycoprotein, expressed in some human malignant cells.

In this work, we evaluate the 14F7 Mab (an IgG1 murine highly specific to N-glycolyl GM3 ganglioside) reactivity in a variety of genitourinary-system-derived tumors as well as in their normal counterparts.

Immunohistochemical assays with 14F7 followed by anti-mouse biotinylated antibody and ABC/HRP system using formalin-fixed and paraffin-embedded tissues were carried out.

In normal tissues, 14F7 was reactive only in renal tubules of kidney (2/6) and in the stromal component and blood vessels of ovary (3/5).

Tumors of kidney (12/38), urinary bladder (8/9), breast (41/42), ovary (21/34), testis (4/5), prostate (17/20), and uterus (5/14) as well as prostatic nodular hyperplasia (5/8) were stained with 14F7.

N-glycolyl GM3 recognized by 14F7 could be considered as one attractive target for both active and passive immunotherapy of genitourinary malignancies expressing this molecule.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Blanco, Rancés& Cedeño, Mercedes& Escobar, Xiomara& Blanco, Damián& Rengifo, Charles E.& Frómeta, Milagros…[et al.]. 2011. Immunorecognition of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Some Normal and Malignant Tissues from Genitourinary System. ISRN Pathology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-511088

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Blanco, Rancés…[et al.]. Immunorecognition of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Some Normal and Malignant Tissues from Genitourinary System. ISRN Pathology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-511088

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Blanco, Rancés& Cedeño, Mercedes& Escobar, Xiomara& Blanco, Damián& Rengifo, Charles E.& Frómeta, Milagros…[et al.]. Immunorecognition of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Some Normal and Malignant Tissues from Genitourinary System. ISRN Pathology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-511088

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-511088