Chronic Cerebral Ischaemia Forms New Cholinergic Mechanisms of Learning and Memory

المؤلفون المشاركون

Zakharova, E. I.
Dudchenko, A. M.
Kubatiev, Aslan
Storozheva, Z. I.

المصدر

International Journal of Alzheimer's Disease

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-17، 17ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-12-20

دولة النشر

مصر

عدد الصفحات

17

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

The purpose of this research was a comparative analysis of cholinergic synaptic organization following learning and memory in normal and chronic cerebral ischaemic rats in the Morris water maze model.

Choline acetyltransferase and protein content were determined in subpopulations of presynapses of “light” and “heavy” synaptosomal fractions of the cortex and the hippocampus, and the cholinergic projective and intrinsic systems of the brain structures were taken into consideration.

We found a strong involvement of cholinergic systems, both projective and intrinsic, in all forms of cognition.

Each form of cognition had an individual cholinergic molecular profile and the cholinergic synaptic compositions in the ischaemic rat brains differed significantly from normal ones.

Our data demonstrated that under ischaemic conditions, instead of damaged connections new key synaptic relationships, which were stable against pathological influences and able to restore damaged cognitive functions, arose.

The plasticity of neurochemical links in the individual organization of certain types of cognition gave a new input into brain pathology and can be used in the future for alternative corrections of vascular and other degenerative dementias.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zakharova, E. I.& Storozheva, Z. I.& Dudchenko, A. M.& Kubatiev, Aslan. 2010. Chronic Cerebral Ischaemia Forms New Cholinergic Mechanisms of Learning and Memory. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-511164

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zakharova, E. I.…[et al.]. Chronic Cerebral Ischaemia Forms New Cholinergic Mechanisms of Learning and Memory. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-511164

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zakharova, E. I.& Storozheva, Z. I.& Dudchenko, A. M.& Kubatiev, Aslan. Chronic Cerebral Ischaemia Forms New Cholinergic Mechanisms of Learning and Memory. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-511164

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-511164