Chronic Cerebral Ischaemia Forms New Cholinergic Mechanisms of Learning and Memory

Joint Authors

Zakharova, E. I.
Dudchenko, A. M.
Kubatiev, Aslan
Storozheva, Z. I.

Source

International Journal of Alzheimer's Disease

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-17, 17 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-12-20

Country of Publication

Egypt

No. of Pages

17

Main Subjects

Diseases
Medicine

Abstract EN

The purpose of this research was a comparative analysis of cholinergic synaptic organization following learning and memory in normal and chronic cerebral ischaemic rats in the Morris water maze model.

Choline acetyltransferase and protein content were determined in subpopulations of presynapses of “light” and “heavy” synaptosomal fractions of the cortex and the hippocampus, and the cholinergic projective and intrinsic systems of the brain structures were taken into consideration.

We found a strong involvement of cholinergic systems, both projective and intrinsic, in all forms of cognition.

Each form of cognition had an individual cholinergic molecular profile and the cholinergic synaptic compositions in the ischaemic rat brains differed significantly from normal ones.

Our data demonstrated that under ischaemic conditions, instead of damaged connections new key synaptic relationships, which were stable against pathological influences and able to restore damaged cognitive functions, arose.

The plasticity of neurochemical links in the individual organization of certain types of cognition gave a new input into brain pathology and can be used in the future for alternative corrections of vascular and other degenerative dementias.

American Psychological Association (APA)

Zakharova, E. I.& Storozheva, Z. I.& Dudchenko, A. M.& Kubatiev, Aslan. 2010. Chronic Cerebral Ischaemia Forms New Cholinergic Mechanisms of Learning and Memory. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-511164

Modern Language Association (MLA)

Zakharova, E. I.…[et al.]. Chronic Cerebral Ischaemia Forms New Cholinergic Mechanisms of Learning and Memory. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-511164

American Medical Association (AMA)

Zakharova, E. I.& Storozheva, Z. I.& Dudchenko, A. M.& Kubatiev, Aslan. Chronic Cerebral Ischaemia Forms New Cholinergic Mechanisms of Learning and Memory. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-511164

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-511164