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Protective Effects of Shen-Yuan-Dan, a Traditional Chinese Medicine, against Myocardial IschemiaReperfusion Injury In Vivo and In Vitro
المؤلفون المشاركون
Chu, Fuyong
Wu, Bao
Yang, Hongzhi
Tong, Tong
Li, Aiyong
Liu, Weihong
Shang, Juju
Liu, Hong-Xu
Xie, Xinran
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objectives.
The study was to investigate the effects and mechanisms of Shen-Yuan-Dan (SYD) pharmacological postconditioning on myocardial ischemia/reperfusion (I/R) injury.
Methods.
In the in vivo experiment, myocardial injury markers and histopathology staining were examined.
In the in vitro experiment, cell viability and cell apoptosis were, respectively, detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and Hoechst 33342 fluorochrome staining.
The protein expressions of Bcl-2 and Bax were determined by immunocytochemistry assay.
Results.
Both low and high doses of SYD protected myocardium against I/R injury in rat model by reducing lactic dehydrogenase (LDH) and creatine kinase-MB (CK-MB) activity and malondialdehyde (MDA) content, increasing superoxide dismutase (SOD) activity and attenuating histopathology injury.
Meanwhile, in the in vitro experiment, SYD promoted cell viability and inhibited the cardiomyocyte apoptosis.
The level of Bcl-2 protein was restored to the normal level by SYD pharmacological postconditioning.
In contrast, the Bax protein level was markedly reduced by SYD pharmacological postconditioning.
These effects of SYD were inhibited by LY294002.
Conclusions.
The results of this study suggested that SYD pharmacological postconditioning has protective effects against myocardial I/R injury in both in vivo and in vitro models, which are related to activating the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Hong-Xu& Shang, Juju& Chu, Fuyong& Li, Aiyong& Wu, Bao& Xie, Xinran…[et al.]. 2013. Protective Effects of Shen-Yuan-Dan, a Traditional Chinese Medicine, against Myocardial IschemiaReperfusion Injury In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-511237
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Hong-Xu…[et al.]. Protective Effects of Shen-Yuan-Dan, a Traditional Chinese Medicine, against Myocardial IschemiaReperfusion Injury In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-511237
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Hong-Xu& Shang, Juju& Chu, Fuyong& Li, Aiyong& Wu, Bao& Xie, Xinran…[et al.]. Protective Effects of Shen-Yuan-Dan, a Traditional Chinese Medicine, against Myocardial IschemiaReperfusion Injury In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-511237
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-511237
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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