Circulating Levels of Interleukin-1 Family Cytokines in Overweight Adolescents

المؤلفون المشاركون

Jung, Christian
Figulla, Hans Reiner
Fritzenwanger, Michael
Gerdes, Norbert

المصدر

Mediators of Inflammation

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-02-09

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الأمراض

الملخص EN

Objectives.

Obesity and related diseases are dramatically increasing problems, particularly in children and adolescents.

We determined circulating levels of different interleukin (IL)-1 family members in normal weight and overweight adolescents.

Methods.

Seventy male, Caucasian adolescents (13–17 years) were recruited.

Thirty-five had a body-mass index (BMI) above the 90th age-specific percentile.

IL-1α, IL-1β, IL-1 receptor antagonist (IL-1ra), and IL-18 were determined using multiplex-technology.

Results.

IL-18 concentrations were higher in the overweight group compared to normal weight (161.6±40.7 pg/ml versus 134.7±43.4 pg/ml, P=.009).

Concentrations of circulating IL-1β levels were below the detection threshold.

IL-18 (R2:0.355, P<.01) and IL-1ra (R2:0.287, P<.05) correlated with BMI, whereas IL-1α did not.

Conclusions.

Accumulating data indicate the importance of the endocrine function of adipose tissue for the pathophysiological consequences of obesity-related co-morbidities.

Since IL-18 is involved in the pathogenesis of different cardiovascular diseases, we conclude that IL-18 may represent a link between obesity and related co-morbidities in children and adolescents.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Jung, Christian& Gerdes, Norbert& Fritzenwanger, Michael& Figulla, Hans Reiner. 2010. Circulating Levels of Interleukin-1 Family Cytokines in Overweight Adolescents. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-511437

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Jung, Christian…[et al.]. Circulating Levels of Interleukin-1 Family Cytokines in Overweight Adolescents. Mediators of Inflammation No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-511437

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Jung, Christian& Gerdes, Norbert& Fritzenwanger, Michael& Figulla, Hans Reiner. Circulating Levels of Interleukin-1 Family Cytokines in Overweight Adolescents. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-511437

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-511437