Circulating Levels of Interleukin-1 Family Cytokines in Overweight Adolescents
Joint Authors
Jung, Christian
Figulla, Hans Reiner
Fritzenwanger, Michael
Gerdes, Norbert
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
Obesity and related diseases are dramatically increasing problems, particularly in children and adolescents.
We determined circulating levels of different interleukin (IL)-1 family members in normal weight and overweight adolescents.
Methods.
Seventy male, Caucasian adolescents (13–17 years) were recruited.
Thirty-five had a body-mass index (BMI) above the 90th age-specific percentile.
IL-1α, IL-1β, IL-1 receptor antagonist (IL-1ra), and IL-18 were determined using multiplex-technology.
Results.
IL-18 concentrations were higher in the overweight group compared to normal weight (161.6±40.7 pg/ml versus 134.7±43.4 pg/ml, P=.009).
Concentrations of circulating IL-1β levels were below the detection threshold.
IL-18 (R2:0.355, P<.01) and IL-1ra (R2:0.287, P<.05) correlated with BMI, whereas IL-1α did not.
Conclusions.
Accumulating data indicate the importance of the endocrine function of adipose tissue for the pathophysiological consequences of obesity-related co-morbidities.
Since IL-18 is involved in the pathogenesis of different cardiovascular diseases, we conclude that IL-18 may represent a link between obesity and related co-morbidities in children and adolescents.
American Psychological Association (APA)
Jung, Christian& Gerdes, Norbert& Fritzenwanger, Michael& Figulla, Hans Reiner. 2010. Circulating Levels of Interleukin-1 Family Cytokines in Overweight Adolescents. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-511437
Modern Language Association (MLA)
Jung, Christian…[et al.]. Circulating Levels of Interleukin-1 Family Cytokines in Overweight Adolescents. Mediators of Inflammation No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-511437
American Medical Association (AMA)
Jung, Christian& Gerdes, Norbert& Fritzenwanger, Michael& Figulla, Hans Reiner. Circulating Levels of Interleukin-1 Family Cytokines in Overweight Adolescents. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-511437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511437