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Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease
المؤلفون المشاركون
Tsuneyama, Koichi
Nakanishi, Yuko
Takasaki, Ichiro
Tabuchi, Yoshiaki
Nishida, Takeshi
Fujimoto, Makoto
Nomoto, Kazuhiro
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Nonalcoholic fatty liver disease (NAFLD) is increasingly recognized as a condition in which excess fat accumulates in hepatocytes.
Nonalcoholic steatohepatitis (NASH), a severe form of NAFLD in which inflammation and fibrosis in the liver are noted, may eventually progress to end-stage liver disease.
Galectin-3, a β-galactoside-binding animal lectin, is a multifunctional protein.
This protein is involved in inflammatory responses and carcinogenesis.
We investigated whether galectin-3 is involved in the development of NASH by comparing galectin-3 knockout (gal3−/−) mice and wild-type (gal3+/+) mice with choline-deficient L-amino-acid-defined (CDAA) diet-induced NAFLD/NASH.
Hepatic injury was significantly more severe in the gal3−/− male mice, as compared to the gal3+/+ mice.
Data generated by microarray analysis of gene expression suggested that galectin-3 deficiency causes alterations in the expression of various genes associated with carcinogenesis and lipid metabolism.
Through canonical pathway analysis, involvement of PDGF and IL-6 signaling pathways was suggested in galectin-3 deficiency.
Significant increase of CD14, Fos, and Jun, those that were related to lipopolysaccharide-mediated signaling, was candidate to promote hepatocellular damages in galectin-3 deficiency.
In conclusion, galectin-3 deficiency in CDAA diet promotes NAFLD features.
It may be caused by alterations in the expression profiles of various hepatic genes including lipopolysaccharide-mediated inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nomoto, Kazuhiro& Nishida, Takeshi& Nakanishi, Yuko& Fujimoto, Makoto& Takasaki, Ichiro& Tabuchi, Yoshiaki…[et al.]. 2012. Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511550
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nomoto, Kazuhiro…[et al.]. Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-511550
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nomoto, Kazuhiro& Nishida, Takeshi& Nakanishi, Yuko& Fujimoto, Makoto& Takasaki, Ichiro& Tabuchi, Yoshiaki…[et al.]. Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511550
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-511550
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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