Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease
Joint Authors
Tsuneyama, Koichi
Nakanishi, Yuko
Takasaki, Ichiro
Tabuchi, Yoshiaki
Nishida, Takeshi
Fujimoto, Makoto
Nomoto, Kazuhiro
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) is increasingly recognized as a condition in which excess fat accumulates in hepatocytes.
Nonalcoholic steatohepatitis (NASH), a severe form of NAFLD in which inflammation and fibrosis in the liver are noted, may eventually progress to end-stage liver disease.
Galectin-3, a β-galactoside-binding animal lectin, is a multifunctional protein.
This protein is involved in inflammatory responses and carcinogenesis.
We investigated whether galectin-3 is involved in the development of NASH by comparing galectin-3 knockout (gal3−/−) mice and wild-type (gal3+/+) mice with choline-deficient L-amino-acid-defined (CDAA) diet-induced NAFLD/NASH.
Hepatic injury was significantly more severe in the gal3−/− male mice, as compared to the gal3+/+ mice.
Data generated by microarray analysis of gene expression suggested that galectin-3 deficiency causes alterations in the expression of various genes associated with carcinogenesis and lipid metabolism.
Through canonical pathway analysis, involvement of PDGF and IL-6 signaling pathways was suggested in galectin-3 deficiency.
Significant increase of CD14, Fos, and Jun, those that were related to lipopolysaccharide-mediated signaling, was candidate to promote hepatocellular damages in galectin-3 deficiency.
In conclusion, galectin-3 deficiency in CDAA diet promotes NAFLD features.
It may be caused by alterations in the expression profiles of various hepatic genes including lipopolysaccharide-mediated inflammation.
American Psychological Association (APA)
Nomoto, Kazuhiro& Nishida, Takeshi& Nakanishi, Yuko& Fujimoto, Makoto& Takasaki, Ichiro& Tabuchi, Yoshiaki…[et al.]. 2012. Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511550
Modern Language Association (MLA)
Nomoto, Kazuhiro…[et al.]. Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-511550
American Medical Association (AMA)
Nomoto, Kazuhiro& Nishida, Takeshi& Nakanishi, Yuko& Fujimoto, Makoto& Takasaki, Ichiro& Tabuchi, Yoshiaki…[et al.]. Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-511550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511550